| Category | Antibody |
| Concentration | 2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form | Antigen affinity purified |
| Conjugation | Unconjugated |
| Clone | Polyclonal antibody |
| Recognised antigen | MAX |
| Host animal | Rabbit (Oryctolagus cuniculus) |
| Clonality | Polyclonal (rabbit origin) |
| Species reactivity | Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications | WB |
| Recommended dilutions | 5-1ug/ml, Western blot: 0 |
| Notes | Titration of the MAX antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use | This MAX antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot # | P61244 |
| Purity | Antigen affinity |
| Description | Both quasisymmetric heterodimers resemble the symmetric MAX homodimer, MAX acts as a classic tumor suppressor gene, Normal lymphocytes from patients showed absence of methylation of the MAX promoter and biallelic expression of the protein, The ability of these cells to divide, The conservation of the sequence is particularly high in the bHLHZ domain, The gene is located on chromosome 14q23 by fluorescence in situ chromosomal hybridization, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these 3 evolutionarily related DNA-binding proteins, and apoptose in the absence of the protein demonstrated for the first time that these processes can occur via Max- and possibly Myc-independent mechanisms, and apoptosis, differentiate, differentiation, which is involved in protein-protein interactions and DNA binding, which ruled out an imprinting-mediated effect on MAX expression, Myc-associated factor X is the most conserved dimerization component of the MYC-MAX-MXD1 network of basic helix-loop-helix leucine zipper(bHLHZ) transcription factors that regulate cell proliferation |
| Immunogen | mouse and rat), Amino acids 32-48 (ERKRRDHIKDSFHSLRD) were used as the immunogen for this MAX antibody (100% homologous in human |
| Storage | Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MAX antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target | MAX |
| Short name | MAX Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | MYC associated factor X (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006461 and protein complex assembly and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016605 and PML body and cellular component this GO :0030425 and dendrite and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032868 and response to insulin and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0046982 and protein heterodimerization activity and molecular function this GO :0046983 and protein dimerization activity and molecular function this GO :0048678 and response to axon injury and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0071339 and MLL1 complex and cellular component this GO :0071375 and cellular response to peptide hormone stimulus and biological process, MAX and IDBG-646780 and ENSBTAG00000017994 and 540616, MAX and IDBG-9524 and ENSG00000125952 and 4149, Max and IDBG-151490 and ENSMUSG00000059436 and 17187, bHLHd4, nuclei, protein dimerization activity, this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003712 and transcription cofactor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003712: transcription cofactor activity and also this GO :0003713: transcription coactivator activity and also this GO :0005515: protein binding and also this GO :0032403: protein complex binding and also this GO :0042803: protein homodimerization activity and also this GO :0043565: sequence-specific DNA binding and also this GO :0046982: protein heterodimerization activity and also this GO :0046983: protein dimerization activity, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003712: transcription cofactor activity, this GO :0003713: transcription coactivator activity, this GO :0005515: protein binding, this GO :0032403: protein complex binding, this GO :0042803: protein homodimerization activity, this GO :0043565: sequence-specific DNA binding, this GO :0046982: protein heterodimerization activity, this GO :0046983: protein dimerization activity, MYC associated factor X |
| Identity | 6913 |
| Gene | MAX |
| Long gene name | MYC associated factor X |
| Synonyms gene name | MAX protein |
| Synonyms | bHLHd4 bHLHd5 bHLHd6 bHLHd7 bHLHd8 |
| Locus | 14q23, 3 |
| Discovery year | 1992-10-27 |
| Entrez gene record | 4149 |
| Pubmed identfication | 1557420 |
| RefSeq identity | NM_197957 |
| Classification | Basic helix-loop-helix proteins |
| Havana BLAST/BLAT | OTTHUMG00000142809 |
| Locus Specific Databases | LRG_530 |
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