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MDC1 Antibody

MDC1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMDC1 Primary Polyclonal Antibody
Also known asMDC1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMDC1
SpecificityThis is a highly specific antibody against MDC1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range45-90/2089
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MDC1
Gene ID number9656
Swiss ProtQ14676
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1, Also required for downstream events subsequent to the recruitment of these proteins, CHEK1 and CHEK2 kinases, May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX, These include phosphorylation and activation of the ATM, and stabilization of TP53 and apoptosis, Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names KIAA0170, MDC1, Mediator of DNA damage checkpoint protein 1, Nuclear factor with BRCT domains 1, NFBD1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMDC1
Short nameMDC1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namemediator on Desoxyribonucleic acid-damage checkpoint 1 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target FHA domain binding, MDC1 and IDBG-634528 and ENSBTAG00000025526 and 511168, MDC1 and IDBG-76700 and ENSG00000137337 and 9656, Mdc1 and IDBG-179187 and ENSMUSG00000061607 and 240087, NFBD1, nuclei, this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005694 and chromosome and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0031573 and intra-S DNA damage checkpoint and biological process this GO :0070975 and FHA domain binding and molecular function, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0008022: protein C-terminus binding and also this GO :0070975: FHA domain binding, this GO :0008022: protein C-terminus binding, this GO :0070975: FHA domain binding, mediator of DNA-damage checkpoint 1
Identity 21163
Gene MDC1
Long gene name mediator of DNA damage checkpoint 1
Synonyms gene name mediator of DNA-damage checkpoint 1
Synonyms NFBD1 KIAA0170 Em:AB023051, 5
Locus 6p21, 33
Discovery year 2003-05-21
GenBank acession D79992
Entrez gene record 9656
Pubmed identfication 10975465 12607005
RefSeq identity NM_014641
Havana BLAST/BLAT OTTHUMG00000031075

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