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MDM2 (Ser166) Antibody

MDM2 (Ser166) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMDM2 (Ser166) Primary Polyclonal Antibody
Also known asMDM2 (Ser166) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMDM2 Ser166
SpecificityThis is a highly specific antibody against MDM2 Ser166
Modification(s)Phosphorylation
Modification site(s)Ser166
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human MDM2 around the phosphorylation site of Ser166
Gene ID number4193
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ARF(P14), Belongs to the MDM2/MDM4 family, Binds p53, Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor, Forms a ternary complex with TP53/p53 and WWOX, Functions as a ubiquitin ligase E3, Interacts with, Interacts with CDKN2AIP, Interacts with PYHIN1, Isoform Mdm2-F does not interact with TP53/p53, MTBP, Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis, TRBG1 and USP7, and ubiquitinates HIV-1 Tat, in the presence of E1 and E2, p73, ribosomal protein L5 and specifically to RNA, toward p53 and itself, Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Double minute 2 protein, HDM2, Hdm 2, MDM 2, MDM2 Ser166, MDM2BP, MTBP, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein mouse binding protein 104kDa, Mouse Double Minute 2, Murine Double Minute Chromosome 2, Oncoprotein Mdm2, Ubiquitin protein ligase E3 Mdm2, p53 Binding Protein Mdm2, MDM2Ser166
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMDM2 (Ser166)
Short nameMDM2 (Ser166) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMDM2 (Ser166) (Antibody to)
Alternative techniqueantibodies
Identity 6973
Gene MDM2
Long gene name MDM2 proto-oncogene
Synonyms gene name E3 ubiquitin protein ligase , human homolog of, mouse double minute 2, p53 binding protein (mouse) Mdm2 p53 binding protein homolog (mouse) MDM2 proto-oncogene, p53-binding protein Mdm2, transformed 3T3 cell double minute 2
Synonyms HDM2 MGC5370
Locus 12q15
Discovery year 1993-12-10
Entrez gene record 4193
Pubmed identfication 1614537 16905769
RefSeq identity NM_006880
Classification Zinc fingers RANBP2-type
Havana BLAST/BLAT OTTHUMG00000142827

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