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MET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody

MET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody
Also known asMET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBi-Phospho-MET/HGFR(Y1234/Y1235)
SpecificityThis is a highly specific antibody against Bi-Phospho-MET/HGFR(Y1234/Y1235)
Modification(s)Phosphorylation
Modification site(s)Y1234/Y1235
ClonalityMonoclonal
Clone number6AT1877
SourceKLH conjugated synthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met and residues both Tyr1234 and Tyr1235 are phosphorylated
Gene ID number4233
Swiss ProtP08581
Tested ApplicationsWB
Recommended dilutionsWB(1:100~500)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a receptor for Listeria internalin inlB, During embryonic development, Following activation by ligand, GRB2, In adults, Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules, MET signaling plays a role in gastrulation, PI3 kinase-AKT, PLCG1, Promotes also differentiation and proliferation of hematopoietic cells, Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, Regulates many physiological processes including proliferation, SRC, STAT3 or the adapter GAB1, The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects, angiogenesis and kidney formation, development and migration of muscles and neuronal precursors, interacts with the PI3-kinase subunit PIK3R1, mediating entry of the pathogen into cells, morphogenesis and survival, or PLCgamma-PKC, participates in wound healing as well as organ regeneration and tissue remodeling, scattering, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand
Purification method This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AUTS9, DFNB97, HGF receptor, HGF/SF receptor, Hepatocyte growth factor receptor, MET, Proto-oncogene c-Met, RCCP2, SF receptor, Scatter factor receptor, Tyrosine-protein kinase Met, c-Met, HGFR
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetMET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal
Short nameMET/HGFR(Y1234/Y1235) (6AT1877) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameMET/HGFR(Y1234/Y1235) (6AT1877) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 20709
Gene SLTM
Long gene name SAFB like transcription modulator
Synonyms Met FLJ13213
Locus 15q22, 1
Discovery year 2005-11-08
GenBank acession BC046119
Entrez gene record 79811
RefSeq identity NM_024755
Classification RNA binding motif containing
Havana BLAST/BLAT OTTHUMG00000074033

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