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Mib1 Antibody

Mib1 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenMib1
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB, IF
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:20-1:100, Western blot: 1:1000
NotesTitration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Mib1 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q86YT6
PurityPurified
Description MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis, which act as ligands of Notch proteins, MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors
ImmunogenA portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Mib1 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetMib1
Short nameMib1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namemindbomb E3 ubiquitin protein ligase 1 (Antibody to)
Alternative techniqueantibodies
Identity 21086
Gene MIB1
Long gene name mindbomb E3 ubiquitin protein ligase 1
Synonyms gene name mindbomb homolog 1 (Drosophila)
Synonyms DIP-1 MIB KIAA1323 ZZANK2 ZZZ6
Locus 18q11, 2
Discovery year 2004-06-18
GenBank acession AB037744
Entrez gene record 57534
RefSeq identity NM_020774
Classification Zinc fingers ZZ-type Ankyrin repeat domain containing
Havana BLAST/BLAT OTTHUMG00000131753
Locus Specific Databases LRG_759

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