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MLL2 Antibody

MLL2 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenMLL2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:500-1:1000
NotesTitration of the MLL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis MLL2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O14686
PurityPurified
Description (2002) found that a key aspect of 82 of these protein sequences is their role in transcription, (2002) identified 192 human protein sequences that have multiple amino acid runs, 5 PHD fingers, By analysis of rodent/human hybrid cells and analysis of the Genebridge radiation hybrid panel, By database searching, Karlin et al, Karlin et al, MLL2 is a striking example of proteins with multiple amino acid runs, The 12q12-q13 region is involved in duplications and translocations associated with cancer, The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides, The gene for MLL2 encodes a 5, They also detected an alternatively spliced form encoding 4, and a long run of glutamines interrupted by hydrophobic residues (mostly leucine), and developmental regulation, including MLL2, including cancer, many of which are associated with disease, potential zinc fingers, such as cancer, they mapped the gene to the 12p13, translation, with 22 glutamine runsGenes encoding a significant number of long amino acid runs are potentially associated with diseases, 1-qter region, 262-amino acid protein containing a SET domain, 957 amino acids and lacking an N-terminal zinc finger and PHD finger, The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family
ImmunogenA portion of amino acids 4980-5009 from the human protein was used as the immunogen for this MLL2 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the MLL2 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetMLL2
Short nameMLL2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namemyeloid/lymphoid and mixed-lineage leukemia 2 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target AAD10 and ALR and CAGL114 and KABUK1 and KMS and MLL2 and MLL4 and TNRC21, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0008168 and methyltransferase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0018024 and histone-lysine N-methyltransferase activity and molecular function this GO :0032259 and methylation and biological process this GO :0033148 and positive regulation of intracellular estrogen receptor signaling pathway and biological process this GO :0035097 and histone methyltransferase complex and cellular component this GO :0043627 and response to estrogen and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048477 and oogenesis and biological process this GO :0051568 and histone H3-K4 methylation and biological process, MLL2 and IDBG-30867 and ENSG00000167548 and 8085, MLL2 and IDBG-632681 and ENSBTAG00000014429 and 506805, Mll2 and IDBG-181423 and ENSMUSG00000048154 and 381022, nuclei, this GO :0001555 and oocyte growth and biological process this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006342 and chromatin silencing and biological process this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0005515: protein binding and also this GO :0008168: methyltransferase activity and also this GO :0008270: zinc ion binding and also this GO :0018024: histone-lysine N-methyltransferase activity and also this GO :0044212: transcription regulatory region DNA binding, this GO :0005515: protein binding, this GO :0008168: methyltransferase activity, this GO :0008270: zinc ion binding, this GO :0018024: histone-lysine N-methyltransferase activity, this GO :0044212: transcription regulatory region DNA binding, transcription regulatory region DNA binding, myeloid/lymphoid or mixed-lineage leukemia 2
Identity 7133
Gene KMT2D
Long gene name lysine methyltransferase 2D
Synonyms gene TNRC21 MLL2
Synonyms gene name trinucleotide repeat containing 21 myeloid/lymphoid or mixed-lineage leukemia 2 lysine (K)-specific methyltransferase 2D
Synonyms ALR MLL4 CAGL114
Locus 12q13, 12
Discovery year 1998-10-14
GenBank acession AF010403
Entrez gene record 8085
Pubmed identfication 9247308
Classification PHD finger proteins Lysine methyltransferases Trinucleotide repeat containing
Havana BLAST/BLAT OTTHUMG00000166524

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