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MMS21 Antibody

MMS21 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMMS21 Primary Polyclonal Antibody
Also known asMMS21 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMMS21
SpecificityThis is a highly specific antibody against MMS21
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MMS21/NSE2
Gene ID number286053
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Depletion of the NSE2 protein by RNA interference leaves the cell vulnerable to DNA damage-induced apoptosis, NSE2 stimulates sumoylation of SMC6 and the DNA repair protein TRAX, Quick and accurate repair of these breaks is crucial for cell survival and genomic stability, SMC5 and SMC6 play a crucial role in DNA repair as they form a complex with six conserved nonSMC subunits, Specifically, Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis, The NSE1 protein contains a RING-like motif that promotes DNA repair functions of the SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells, including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2, this complex is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements, Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names E3 SUMO-protein ligase NSE2, MMS21, MMS21 homolog, NSE2_HUMAN, NSMCE2, Non-SMC element 2 homolog, Non-structural maintenance of chromosomes element 2 homolog, hMMS21, hNSE2, methyl methanesulfonate sensitivity gene 21, non-SMC element 2, C8orf36
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMMS21
Short nameMMS21 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMMS21 (Antibody to)
Alternative techniqueantibodies
Identity 26513
Gene NSMCE2
Long gene name NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Synonyms gene C8orf36
Synonyms gene name MMS21 homolog (S, S, cerevisiae) , cerevisiae) non-SMC element 2, chromosome 8 open reading frame 36 non-SMC element 2 homolog (MMS21
Synonyms FLJ32440 MMS21 NSE2 ZMIZ7
Synonyms name MIZ-type containing 7 , zinc finger
Locus 8q24, 13
Discovery year 2005-07-27
GenBank acession AK057002
Entrez gene record 286053
Pubmed identfication 16055714 21550342
RefSeq identity NM_173685
Classification SMC5-6 protein complex Zinc fingers MIZ-type
Havana BLAST/BLAT OTTHUMG00000164993

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