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MOUSE Anti-HUMAN GLUTAMATE DECARBOXYLASE 2 (N-TERMINAL) Antibody

MOUSE Anti-HUMAN GLUTAMATE DECARBOXYLASE 2 (N-TERMINAL) Antibody size: 200ug 453

Supplier MBS MONO
Price 453
Size 200ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asGLUTAMATE DECARBOXYLASE 2
Other names 65 kDa glutamic acid decarboxylase, 65 kDa glutamic acid decarboxylase, 65kDa), GAD-65, GAD-65, Glutamate decarboxylase 2, Glutamate decarboxylase 65 kDa isoform, Glutamate decarboxylase-2 (pancreas), glutamate decarboxylase 2, glutamate decarboxylase 2 (pancreatic islets and brain, glutamate decarboxylase 65 kDa isoform, glutamate decarboxylase 2
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene name GAD-65, GAD2, GAD65, GAD65, GAD2
Gene name synonims GAD-65, GAD2, GAD65, GAD65, GAD2
Other gene names GAD-65, GAD2, GAD65, GAD65, GAD2
ClonalityMonoclonal
Immunoglobulin isotypeIgG1
CloneN-GAD65
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity Clone N-GAD65 has been shown to be highly specific for GAD65 and does not recognise GAD67, GAD65 catalyzes the decarboxylation of glutamate to GABA, GAD65 is the 65kDa isoform of GAD, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have shown the presence of autoantibodies to GAD65 (GAD65Ab) in autoimmune diseases, The N-Terminal region of GAD65 lacks the epitopes for GAD65Ab in Type I diabetes patients, This particular antibody might cross react with speacies outside of the listed ones, an ampiphilic membrane-anchored protein and member of the group 2 decarboxylase family, and has been shown as essential for targeting the enzyme to GABA-containing secretory vesicles, and is encoded by the GAD1 gene, and those at high risk of developing Type I diabetes, as oppose to the 67kDa isoform (GAD67), but GAD65Ab are most prevalent in patients with Type I diabetes mellitus, encoded by the GAD2 gene, including Graves' disease and Stiff Man Syndrome (SMS), otherwise known as GAD65/GAD2, principally expressed in the brain and also in pancreatic beta cells, the major inhibitory neurotransmitter in the central nervous system, which is predominantly expressed by nerve termini, which is predominantly found in the cell body, GLUTAMATE DECARBOXYLASE 2 This item specifically recognises an epitope within the N-terminal (NT) region of Glutamate decarboxylase 2
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications: Immunoprecipitation (IP), RadioImmunoassay (RIA), Western Blot (WB), Immunohistology - Paraffin (IHC)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetGLUTAMATE DECARBOXYLASE 2
Short nameMOUSE Anti-HUMAN GLUTAMATE DECARBOXYLASE 2 (N-TERMINAL) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens GLUTAMATE DECARBOXYLASE 2 (N-TERMINAL) (Antibody to), MOUSE antibody to-H
Alternative techniqueantibodies
Identity 4093
Gene GAD2
Long gene name glutamate decarboxylase 2
Synonyms gene name 65kD) glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) , glutamate decarboxylase 2 (pancreatic islets and brain
Synonyms GAD65
Locus 10p12, 1
Discovery year 1991-11-29
GenBank acession AJ251501
Entrez gene record 2572
Pubmed identfication 2039509
RefSeq identity NM_000818
Havana BLAST/BLAT OTTHUMG00000017836

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