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MOUSE Anti-HUMAN LMO2 Antibody

MOUSE Anti-HUMAN LMO2 Antibody size: 100ug 475

Supplier MBS MONO
Price 475
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asLMO2
Other names Cysteine-rich protein TTG-2, LIM domain only 2 (rhombotin-like 1), LIM domain only protein 2, LIM domain only protein 2, LMO-2, LMO-2, Rhombotin-2, T-cell translocation gene 2, T-cell translocation protein 2, T-cell translocation protein 2, cysteine-rich protein TTG-2, rhombotin 2, rhombotin-2, rhombotin-like 1, rhombotin-2 isoform 2
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameLMO2
Gene name synonimsN/A
Other gene names LMO-2, LMO2, RBTN2, RBTN2, RBTNL1, RBTNL1, RHOM2, RHOM2, TTG2, TTG2, LMO2
ClonalityMonoclonal
Immunoglobulin isotypeIgG1
Clone1A9-1
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity Activation of the Notch signalling pathway by mutations in either the gamma-secretase or PEST domains are found in more than 50% of all T-ALL, In early development, LMO1/2, LMO2 is expressed in the central nervous system and a wide range of tissue, LMO2 plays a vital role in early stages of haematopoiesis and in regulating yolk-sac erythropoiesis in mice, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies suggest that it may also play a role in angiogenesis, This particular antibody might cross react with speacies outside of the listed ones, _x000D_A major cause of T-cell acute lymphoblastic leukemia (T-ALL) is the aberrant activation of the TAL1/SCL, _x000D__x000D_Aberrant expression of LMO2 has also been linked to certain types of B-cell lymphoma, a 24kD transcription factor that interacts with DNA binding proteins such as TAL1/SCL and GATA1, and LMO2 is reported to be expressed in prostate cancer, and NOTCH1 oncogenes, and in adults in myeloid and erythroid precursors, and studies using mouse models, endothelial cells and parts of the brain, have show that activation of Notch co-operates with Scl/Lmo1 in inducing T-ALL, in normal germinal centre B-cells, including LMO2-induced T-ALL, with overexpression possibly linked to cancer progression, LMO2 This item recognises the human LIM-only protein (LMO2), _x000D_
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0 mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications: Immunohistology - Paraffin (IHC), Western Blot (WB), Immunofluorescence (IF)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetLMO2
Short nameMOUSE Anti-HUMAN LMO2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens LMO2 (Antibody to), MOUSE antibody to-H
Alternative techniqueantibodies
Identity 6642
Gene LMO2
Long gene name LIM domain only 2
Synonyms gene RBTNL1
Synonyms gene name rhombotin-like 1
Synonyms TTG2 RHOM2 RBTN2
Synonyms name T-cell translocation gene 2 rhombotin-like 1
Locus 11p13
Discovery year 1991-08-21
GenBank acession X61118
Entrez gene record 4005
Pubmed identfication 2034676
RefSeq identity NM_005574
Classification LIM domain containing
Havana BLAST/BLAT OTTHUMG00000157176

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