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MOUSE Anti-HUMAN SIGLEC-10 Antibody

MOUSE Anti-HUMAN SIGLEC-10 Antibody size: 100ug 398

Supplier MBS MONO
Price 398
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asSIGLEC-10
Other names Sialic acid-binding Ig-like lectin 10, Siglec-like protein 2, sialic acid binding Ig-like lectin 10, sialic acid binding Ig-like lectin 10 Ig-like lectin 7, sialic acid-binding Ig-like lectin 10, siglec-like gene 2, siglec-like protein 2, sialic acid-binding Ig-like lectin 10 isoform 2
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameSIGLEC-10
Gene name synonimsN/A
Other gene names PRO940, SIGLEC-10, SIGLEC10, SLG2, SLG2, Siglec-10, SIGLEC10
ClonalityMonoclonal
Immunoglobulin isotypeIgG1
Clone5G6
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity 5, 7, 8 and 9_x000D__x000D_, B cells, Siglec-10 is most similar to the CD33-related group of Siglecs, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Structurally, _x000D__x000D_Studies have shown that clone 5G6 does not cross-react with Siglecs 3, a glycoprotein expressed on endothelium during inflammation, a putative adhesion molecule and member of the Ig superfamily, and at a higher level by a subpopulation of CD16<, and preferentially binds to glycoconjugates containing alpha-2, eosinophils, expressed by monocytes, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment, natural killer (NK) cells, which is involved in primary amine oxidation and leucocyte trafficking This interaction between Siglec-10 and VAP-1, +<, -<, /sup>, /sup>, 3- or alpha-2, 6-linked sialic acid, CD56<, SIGLEC-10 Clone 5G6 specifically recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), sup>, sup>
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0 mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:Flow Cytometry (FACS)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetSIGLEC-10
Short nameMOUSE Anti-HUMAN SIGLEC-10 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens SIGLEC-10 (Antibody to), MOUSE antibody to-H
Alternative techniqueantibodies
Identity 15620
Gene SIGLEC10
Long gene name sialic acid binding Ig like lectin 10
Synonyms gene name sialic acid binding Ig-like lectin 10
Synonyms SIGLEC-10 SLG2 PRO940 MGC126774
Synonyms name sialic acid binding Ig-like lectin 10 Ig-like lectin 7 siglec-like gene 2
Locus 19q13, 41
Discovery year 2001-06-29
GenBank acession AF310233
Entrez gene record 89790
Pubmed identfication 11284738
RefSeq identity NM_033130
Classification C2-set domain containing Sialic acid binding Ig like lectins V-set domain containing
Havana BLAST/BLAT OTTHUMG00000165521

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