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MRP4 Antibody

MRP4 Antibody size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenMRP4
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0
NotesTitration of the MRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis MRP4 antibodyis to be used only for research purposes and not for diagnostics
Gene ID #10257
PurityAntigen affinity
Description ABCC4/MRP4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus, It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells, It has been found that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response, Pharmacologic inhibition of its activity or knockdown of the protein via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells, The antiproliferative effect of MPR4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation, This gene is mapped to chromosome 13q32, is a protein that in humans is encoded by the ABCC4 gene, member 4) also known as MRP4 (Multidrug resistance associated protein 4) or MOATB, subfamily c, ABCC4 (ATP-binding cassette
ImmunogenHuman partial recombinant protein (AA 1-370) was used as the immunogen for this MRP4 antibody
Storage After reconstitution, Avoid repeated freezing and thawing, Celcius or lower, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, The lyophilized MRP4 antibody can be stored at 4oC to -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetMRP4
Short nameMRP4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMRP4 (Antibody to)
Alternative techniqueantibodies
Identity 55
Gene ABCC4
Long gene name ATP binding cassette subfamily C member 4
Synonyms gene name ATP-binding cassette, member 4 , sub-family C (CFTR/MRP)
Synonyms MRP4 EST170205 MOAT-B MOATB
Synonyms name canalicular multispecific organic anion transporter (ABC superfamily) bA464I2, member 4) multidrug resistance-associated protein 4 multispecific organic anion transporter B , sub-family C (CFTR/MRP), 1 (ATP-binding cassette
Locus 13q32, 1
Discovery year 1999-10-26
GenBank acession U66682
Entrez gene record 10257
Pubmed identfication 8894702 9661885
RefSeq identity NM_005845
Classification ATP binding cassette subfamily C
Havana BLAST/BLAT OTTHUMG00000017216

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