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MSK2 Antibody

MSK2 Antibody size: 0.1ml 354

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 354
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMSK2 Primary Polyclonal Antibody
Also known asMSK2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMSK2
SpecificityThis is a highly specific antibody against MSK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
SourceSynthetic peptide
Gene ID number8986
Swiss ProtO75676
Tested Applications IHC-P, WB
Recommended dilutions IHC-P, 000), WB (1:2
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), In lipopolysaccharide-stimulated primary macrophages, May also phosphorylate 'Ser-28' of histone H3, Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14), Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, Plays an essential role in the control of RELA transcriptional activity in response to TNF, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes, epidermal growth factor (EGF) and anisomycin, including proto-oncogenes c-fos/FOS and c-jun/JUN, stress stimuli and EGF, via CREB1 and ATF1 transcription factors, which results in the transcriptional activation of several immediate early genes, Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, RPS6KA4, RSK-B, RSKB, Ribosomal protein S6 kinase alpha-4, Ribosomal protein kinase B, S6K-alpha-4, MSK2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMSK2
Short nameMSK2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMSK2 (Antibody to)
Alternative techniqueantibodies
Identity 10433
Gene RPS6KA4
Long gene name ribosomal protein S6 kinase A4
Synonyms gene name 90kD, polypeptide 4 , ribosomal protein S6 kinase
Synonyms RSK-B MSK2
Locus 11q13, 1
Discovery year 1999-03-10
GenBank acession AJ010119
Entrez gene record 8986
Pubmed identfication 9792677 9687510
RefSeq identity NM_003942
Classification Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000046094

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