MST1 Antibody

MST1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	MST1 Primary Polyclonal Antibody
Also known as	MST1 PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	MST1
Specificity	This is a highly specific antibody against MST1
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	400-450/487
Subcellular location	Nucleus, Cytoplasm
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MST1
Gene ID number	6789
Swiss Prot	Q13043
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	Acts as an inhibitor of PKB/AKT1, Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, MOBKL1B and RASSF2, Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis, Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes, Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner, Phosphorylates FOXO3 upon oxidative stress, Phosphorylates MOBKL1A, Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T), Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, and to inhibit tumor formation (By similarity), cell death, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation, following caspase-cleavage, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, pro-apoptotic kinase which, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage, to prevent activation of facultative adult liver stem cells (oval cells), which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, which results in its nuclear translocation and cell death initiation, Stress-activated
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	MST-1, MST1, Mammalian STE20-like protein kinase 1, STE20-like kinase MST1, STK4, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase Krs-2, TIIAC, YSK3, KRS2
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	MST1
Short name	MST1 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	macrophage stimulating 1 (hepatocyte growth factor-like) (Antibody to)
Alternative technique	antibodies
Alternative to gene target	BT, D3F15S2 and DNF15S2 and HGFL and MSP and NF15S2, MST1 and IDBG-35033 and ENSG00000173531 and 4485, Mst1 and IDBG-199175 and ENSMUSG00000032591 and 15235, multiple, serine-type endopeptidase activity, this GO :0003674 and molecular function and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0006508 and proteolysis and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007566 and embryo implantation and biological process this GO :0008150 and biological process and biological process this GO :0030317 and sperm motility and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0003674: molecular_function, this GO :0003674: molecular_function and also this GO :0003824: catalytic activity and also this GO :0004252: serine-type endopeptidase activity, this GO :0003824: catalytic activity, this GO :0004252: serine-type endopeptidase activity, 60953 and IDBG-645967 and ENSBTAG00000011585 and 514667, macrophage stimulating 1 (hepatocyte growth factor-like)
Identity	11408
Gene	STK4
Long gene name	serine/threonine kinase 4
Synonyms	MST1 KRS2 YSK3
Synonyms name	mammalian sterile 20-like 1 yeast Ste20-like kinase responsive to stress 2
Locus	20q13, 12
Discovery year	1997-10-09
Entrez gene record	6789
Pubmed identfication	8816758 9545236 11517310
RefSeq identity	NM_006282
Havana BLAST/BLAT	OTTHUMG00000033059
Locus Specific Databases	LRG_535

MST1 Antibody

MST1 Antibody size: 0.1ml 263

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