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MYPT1 (Ser668) Antibody

MYPT1 (Ser668) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMYPT1 (Ser668) Primary Polyclonal Antibody
Also known asMYPT1 (Ser668) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMYPT1 Ser668
SpecificityThis is a highly specific antibody against MYPT1 Ser668
Modification(s)Phosphorylation
Modification site(s)Ser668
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human around the phosphorylation site of Ser668
Gene ID number4659
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC, Rho associated kinase (Rho kinase), RhoA, The guanosine triphosphate (GTP) bound, The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, Therefore Rho appears to inhibit myosin phosphatase through the action of Rho kinase, active form of RhoA (GTP, phosphorylated MBS and consequently inactivated myosin phosphatase, which is activated by GTP, which regulates the extent of phosphorylation of MLC, which results in contraction of smooth muscle and interaction of actin and myosin in non muscle cells, Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho, RhoA) specifically interacted with the myosin binding subunit (MBS) of myosin phosphatase
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names M130, MBS, MGC133042, MYPT 1, MYPT1, MYPT1_HUMAN, Myosin Phosphatase, Myosin Phosphatase phospho S668, Myosin Phosphatase phospho Ser668, Myosin phosphatase target subunit 1, Myosin phosphatase targeting subunit 1, Myosin phosphatase-targeting subunit 1, PPP1R12A, Protein phosphatase 1 regulatory inhibitor subunit 12A, Protein phosphatase 1 regulatory subunit 12A, Protein phosphatase myosin binding subunit, Protein phosphatase myosin-binding subunit, p-MYPT1Ser668, MYPT1 Ser668
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMYPT1 (Ser668)
Short nameMYPT1 (Ser668) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMYPT1 (Ser668) (Antibody to)
Alternative techniqueantibodies
Identity 7618
Gene PPP1R12A
Long gene name protein phosphatase 1 regulatory subunit 12A
Synonyms gene MYPT1
Synonyms gene name protein phosphatase 1, regulatory (inhibitor) subunit 12A protein phosphatase 1, regulatory subunit 12A
Synonyms MBS M130
Synonyms name myosin phosphatase-targeting subunit 1 myosin binding subunit
Locus 12q21, 2-q21, 31
Discovery year 1997-12-23
GenBank acession D87930
Entrez gene record 4659
Pubmed identfication 9286714
RefSeq identity NM_002480
Classification Ankyrin repeat domain containing Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000170100

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