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NIPA Antibody

NIPA Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNIPA Primary Polyclonal Antibody
Also known asNIPA PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNIPA
SpecificityThis is a highly specific antibody against NIPA
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NIPA
Gene ID number51530
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry, Nuclear cyclin B1 is a substrate of SCFNIPA, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle, The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, Thus, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry, which restricts substrate ubiquitination activity to interphase, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core, The regulated oscillation of protein expression is an essential mechanism of cell cycle control
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names NIPA_HUMAN, Nuclear interacting partner of ALK, Nuclear interacting partner of anaplastic lymphoma kinase, ZC3HC1, Zinc finger C3HC type containing 1, hNIPA
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNIPA
Short nameNIPA Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNIPA (Antibody to)
Alternative techniqueantibodies
Identity 29913
Gene ZC3HC1
Long gene name zinc finger C3HC-type containing 1
Synonyms NIPA
Synonyms name nuclear interaction partner of ALK
Locus 7q32, 2
Discovery year 2004-11-19
GenBank acession AF151050
Entrez gene record 51530
Pubmed identfication 11042152
RefSeq identity NM_016478
Classification Zinc fingers
Havana BLAST/BLAT OTTHUMG00000157648

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