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NOTCH Antibody

NOTCH Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenNOTCH
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:1000
NotesTitration of the NOTCH antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis NOTCH antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P46531
PurityAntigen affinity
Description Affects the implementation of differentiation, During cerebellar development, Important for follicular differentiation and possibly cell fate selection within the follicle, Involved in angiogenesis, Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO), Involved in the maturation of both CD4+ and CD8+ cells in the thymus, Jagged2 and Delta1 to regulate cell-fate determination, May be involved in mesoderm development, May enhance HIF1A function by sequestering HIF1AN away from HIF1A, May play an essential role in postimplantation development, Represses neuronal and myogenic differentiation, Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury, Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus, [UniProt], functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting, probably in some aspect of cell specification and/or differentiation, proliferation and apoptotic programs, somite formation and neurogenesis, Functions as a receptor for membrane-bound ligands Jagged1
ImmunogenThis NOTCH antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 2428-2462 amino acids from the C-terminal region of human NOTCH1
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the NOTCH antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetNOTCH
Short nameNOTCH Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNOTCH (Antibody to)
Alternative techniqueantibodies
Identity 5567
Gene IGHV1OR15-5
Long gene name immunoglobulin heavy variable 1/OR15-5 (non-functional)
Synonyms gene name immunoglobulin heavy variable 1/OR15-5 immunoglobulin heavy variable 1/OR15-5 pseudogene immunoglobulin heavy variable 1/OR15-5 (pseudogene)
Synonyms IGHV1/OR15-5
Locus 15q11, 2 not on reference assembly
Discovery year 2000-04-17
GenBank acession Z29633
Entrez gene record 100384884
RefSeq identity NG_016978
Classification Immunoglobulin heavy (IGH) orphons

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