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OPG Antibody Osteoprotegerin

OPG Antibody Osteoprotegerin size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenOPG Osteoprotegerin
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the OPG antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis OPG antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O00300
PurityAntigen affinity
Description By analysis of radiation hybrids, By binding RANKL, OPG inhibits nuclear kappa B (NF-kappa B) which is a central and rapid acting transcription factor for immune-related genes, OPG is a cytokine receptor, Osteoprotegerin binding to RANKL on osteoblast/stromal cells, TNFRSF11B gene was mapped to chromosome 8q24, The protein is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL), also known as Osteoprotegerin and OPG, and a key regulator of inflammation, and a member of the tumor necrosis factor (TNF) receptor superfamily, and cell survival and differentiation, blocks the RANK-RANK ligand interaction between osteoblast/stromal cells and ostepclast precursors, innate immunity, is a protein that in humans is encoded by the TNFRSF11B gene, Tumor necrosis factor receptor superfamily member 11B
ImmunogenAn amino acid sequence from the C-terminus of human Osteoprotegerin (IRFLHSFTMYKLYQKLFLEMI) was used as the immunogen for this OPG antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the OPG antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetOPG Osteoprotegerin
Short nameOPG Antibody Osteoprotegerin
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameOPG (Antibody to) Osteoprotegerin
Alternative techniqueantibodies
Identity 11909
Gene TNFRSF11B
Long gene name TNF receptor superfamily member 11b
Synonyms gene OPG
Synonyms gene name member 11b , osteoprotegerin tumor necrosis factor receptor superfamily
Synonyms OCIF TR1
Locus 8q24, 12
Discovery year 1997-09-05
GenBank acession U94332
Entrez gene record 4982
Pubmed identfication 9108485
Classification Tumor necrosis factor receptor superfamily
Havana BLAST/BLAT OTTHUMG00000164969

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