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P105 RB Antibody, Cy7 Conjugated

P105 RB Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, P105 RB Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenP105 RB
SpecificityThis is a highly specific antibody against P105 RB
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range68-116/928
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human Rb/P105 RB
Gene ID number5925
Swiss ProtP06400
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a transcription repressor of E2F1 target genes, Controls histone H4 'Lys-2' trimethylation, Directly involved in heterochromatin formation by maintaining overall chromatin structure and, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity, In case of viral infections, In resting neurons, Inhibits the intrinsic kinase activity of TAF1, Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter, Promotes G-G1 transition when phosphorylated by CDK3/cyclin-C, RB1 is dephosphorylated by calcineurin, Recruits and targets histone methyltransferases SUV39H1, SUV42H1 and SUV42H2, The underphosphorylated, Upon calcium influx, active form of RB1 interacts with E2F1 and represses its transcription activity, in particular, interactions with SV4 large T antigen, leading to cell cycle arrest, leading to epigenetic transcriptional repression, that of constitutive heterochromatin by stabilizing histone methylation, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex, which leads to release of the repressor complex (By similarity), Key regulator of entry into cell division that acts as a tumor suppressor
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms LYT-10 p52 p105 NF-kB2 p49/p100
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetP105 RB Conjugated
Short name Conjugated, P105 RB Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, P105 RB (Antibody to)
Alternative techniqueantibodies
Identity 7795
Gene NFKB2
Long gene name nuclear factor kappa B subunit 2
Synonyms gene name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Locus 10q24, 32
Discovery year 1991-11-14
GenBank acession X61498
Entrez gene record 4791
Pubmed identfication 1876189
Classification Ankyrin repeat domain containing NF-kappa B complex subunits
Havana BLAST/BLAT OTTHUMG00000018962

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