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p95 NBS1 Antibody, ALEXA FLUOR 350

p95 NBS1 Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, p95 NBS1 Polyclonal Antibody
Also known asAnti-p95 NBS1 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target Antigenp95 NBS1
SpecificityThis is a highly specific antibody against p95 NBS1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range700-754/754
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NBS1
Gene ID Number4683
Swiss ProtO60934
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen ATR, DNA recombination, Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex, Forms a complex with RBBP8 to link DNA double-strand break sensing to resection, It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX, NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation, NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints, NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex is involved in double-strand break (DSB) repair, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, The roles of NBS1/MRN encompass DNA damage sensor, and effector, and probably DNA-PKcs to the DNA damage sites and activating their functions, cell cycle checkpoint control and meiosis, maintenance of telomere integrity, signal transducer, which are provided by MRE11A, which enable cells to maintain DNA integrity and genomic stability, Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms ATV AT-V2 AT-V1
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetp95 NBS1
Short namep95 NBS1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, p95 NBS1 (Antibody to)
Alternative techniqueantibodies
Identity 7652
Gene NBN
Long gene name nibrin
Synonyms gene NBS NBS1
Synonyms gene name Nijmegen breakage syndrome 1 (nibrin)
Locus 8q21, 3
Discovery year 1997-11-28
GenBank acession AF058696
Entrez gene record 4683
Pubmed identfication 9590181 9590180
RefSeq identity NM_001024688
Classification BRCA1 C complex MRN complex
Havana BLAST/BLAT OTTHUMG00000153546
Locus Specific Databases LOVD - Leiden Open Variation Database LRG_158

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