PALB2 Antibody

PALB2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	PALB2 Primary Polyclonal Antibody
Also known as	PALB2 PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	PALB2
Specificity	This is a highly specific antibody against PALB2
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	1100-1150/1186
Subcellular location	Nucleus
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PALB2
Gene ID number	79728
Swiss Prot	Q86YC2
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	Also enables its recombinational repair and checkpoint functions of BRCA2, Binds DNA with high affinity for D loop, Essential partner of BRCA2 that promotes the localization and stability of BRCA2, Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51, May act by promoting stable association of BRCA2 with nuclear structures, May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination, Strongly stimulates the DNA strand-invasion activity of RAD51, Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair, allowing BRCA2 to escape the effects of proteasome-mediated degradation, double-stranded and branched DNA structures, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA), together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity, which comprises single-stranded, Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	PALB2, PNCA3, Partner and localizer of BRCA2, FANCN
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	PALB2
Short name	PALB2 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	PALB2 (Antibody to)
Alternative technique	antibodies
Identity	26144
Gene	PALB2
Long gene name	partner and localizer of BRCA2
Synonyms	FLJ21816 FANCN
Synonyms name	Fanconi anemia, complementation group N
Locus	16p12, 2
Discovery year	2007-01-15
Entrez gene record	79728
Pubmed identfication	16793542 17200672
RefSeq identity	NM_024675
Classification	Fanconi anemia complementation groups
Havana BLAST/BLAT	OTTHUMG00000177097
Locus Specific Databases	Fanconi anemia database LRG_308

PALB2 Antibody

PALB2 Antibody size: 0.1ml 263

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