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Pan-ras Antibody

Pan-ras Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePan-ras Primary Polyclonal Antibody
Also known asPan-ras PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPan-ras
SpecificityThis is a highly specific antibody against Pan-ras
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Pan-ras
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A high incidence of RAS mutations is found in pancreatic cancers, NRAS and KRAS, PDGFR, RAS mutations are found in 10-15% of tumours, Ras proteins are membrane-bound GTPases, Single amino acid substitutions can activate RAS making it highly oncogenic, Such mutations generally reduce the GTPase activity of RAS, The consequence of this is sustained activation of the RAF1-MAPK signalling pathway, The inactive form is GDP-bound, The main genes are HRAS, These kinases transiently convert RAS-GDP to RAS-GTP, They are activated by ligand-binding receptor tyrosine kinases such as EGFR, colony-stimulating factor and fibroblast growth factor, prolonging it in its active GTP-bound form, the active form of RAS, RAS superfamily comprises around 50 related genes encoding GTP-binding domain (G-proteins) involved in signal transduction
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names H-Ras-1, N-Ras, P21 protein, c-H-ras, p21ras, K-Ras
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPan-ras
Short namePan-ras Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePan-ras (Antibody to)
Alternative techniqueantibodies

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