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PARK7 Antibody, Biotin Conjugated

PARK7 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, PARK7 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenPARK7
SpecificityThis is a highly specific antibody against PARK7
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range130-189/189
Subcellular location Cell membrane, Mitochondrion, Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human PARK7
Gene ID number11315
Swiss ProtQ99497
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts on early glycation intermediates (hemithioacetals and aminocarbinols), Deglycates cysteines, Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825), It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, Its involvement in protein repair could also explain other unrelated functions, Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745), Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease, PubMed:12796482, PubMed:14749723, PubMed:15502874, PubMed:16632486), PubMed:17015834, PubMed:18711745, PubMed:18711745), PubMed:19229105, PubMed:20304780, PubMed:21097510, PubMed:25416785), Regulates astrocyte inflammatory responses, Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, and releases repaired proteins and lactate or glycolate, and thus reactivates these proteins by reversing glycation by glyoxals, arginines and lysines residues in proteins, for instance, functions probably related to its primary function (PubMed:17015834, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785), respectively, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms DJ-1 DJ1
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetPARK7 Conjugated
Short name Conjugated, PARK7 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, PARK7 (Antibody to)
Alternative techniqueantibodies
Identity 16369
Gene PARK7
Long gene name Parkinsonism associated deglycase
Synonyms gene name Parkinson disease (autosomal recessive, early onset) 7 parkinson protein 7
Locus 1p36, 23
Discovery year 2001-08-07
GenBank acession D61380
Entrez gene record 11315
Pubmed identfication 11462174 9070310 25416785
RefSeq identity NM_007262
Classification Parkinson disease associated genes
Havana BLAST/BLAT OTTHUMG00000001210
Locus Specific Databases Parkinson', s disease Mutation Database

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