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PARK8 Antibody

PARK8 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPARK8
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IF, WB
Recommended dilutionsImmunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the PARK8 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis PARK8 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q5S007
PurityAntigen affinity
Description 6 disease-segregating mutations (5 missense and 1 putative splice site mutation), About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease, By high-resolution recombination mapping and candidate gene sequencing in 46 families, It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism, LRRK2/PARK8, PARK8 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains, The mutation is the most common cause of Parkinson's disease identified to date, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease, Parkinson is the second most common neurodegenerative disease after Alzheimers
ImmunogenA portion of amino acids 930-961 from the human protein was used as the immunogen for this PARK8 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PARK8 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPARK8
Short namePARK8 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePARK8 (Antibody to)
Alternative techniqueantibodies
Identity 18618
Gene LRRK2
Long gene name leucine rich repeat kinase 2
Synonyms gene PARK8
Synonyms gene name Parkinson disease (autosomal dominant) 8
Synonyms ROCO2 DKFZp434H2111 FLJ45829 RIPK7
Locus 12q12
Discovery year 2004-10-22
GenBank acession AK026776
Entrez gene record 120892
Pubmed identfication 15541308
RefSeq identity XM_058513
Classification Parkinson disease associated genes
Havana BLAST/BLAT OTTHUMG00000059742
Locus Specific Databases Parkinson', s disease Mutation Database

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