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PBP Antibody

PBP Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPBP
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus)
Tested applications IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0
Notes Titration of the PBP antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis PBP antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P70296
PurityAntigen affinity
Description Depletion of the protein decreased the mitotic index, Overexpression interferes with the activation of MEK and ERK, PBP coimmunoprecipitates with RAF1 and MEK from cell lysates and colocalizes with RAF1 when examined by confocal microscopy, PBP expression was rapidly upregulated during induction of chemotherapy-triggered apoptosis in human prostate and breast cancer cell lines, and an override of mitotic checkpoints induced by spindle poisons, and maximal expression correlated perfectly with the onset of apoptosis by Chatterjee et al(2004), and transformation elicited by an oncogenically activated RAF1 kinase, induction of AP1-dependent reporter genes, the number of metaphase cells, traversal times from nuclear envelope breakdown to anaphase, Phosphatidylethanolamine-binding protein inhibits the phosphorylation and activation of MEK by RAF1
ImmunogenAn amino acid sequence from the N-terminus of mouse PBP (QEVDEPPQHALRVDY) was used as the immunogen for this PBP antibody (100% rat homology)
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PBP antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPBP
Short namePBP Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePBP (Antibody to)
Alternative techniqueantibodies
Identity 2989
Gene DOCK3
Long gene name dedicator of cytokinesis 3
Synonyms gene name dedicator of cyto-kinesis 3
Synonyms KIAA0299 MOCA PBP
Locus 3p21, 2
Discovery year 1998-05-13
GenBank acession AB002297
Entrez gene record 1795
Pubmed identfication 9205841
RefSeq identity NM_004947
Havana BLAST/BLAT OTTHUMG00000156892

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