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PHF1 Antibody

PHF1 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPHF1
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:1000
NotesTitration of the PHF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis PHF1 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O43189
PurityAntigen affinity
Description According to another report, According to some reports, Acts by binding to H3K36me3, Involved in DNA damage response and is recruited at double-strand breaks (DSBs), PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980), PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982), Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex, Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex
ImmunogenThis PHF1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the N-terminal region of human PHF1
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PHF1 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPHF1
Short namePHF1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePHF1 (Antibody to)
Alternative techniqueantibodies
Identity 8919
Gene PHF1
Long gene name PHD finger protein 1
Synonyms MTF2L2 TDRD19C PCL1
Synonyms name tudor domain containing 19C polycomb-like 1
Locus 6p21, 32
Discovery year 1997-10-10
GenBank acession AF029678
Entrez gene record 5252
Pubmed identfication 9545646 18385154
Classification PHD finger proteins Tudor domain containing
Havana BLAST/BLAT OTTHUMG00000031105

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