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PIWIL2 (11C11) Monoclonal Antibody

PIWIL2 (11C11) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePIWIL2 (11C11) Monoclonal Antibody
Also known asPIWIL2 (11C11) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPIWIL2
SpecificityThis is a highly specific antibody against PIWIL2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number11C11
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli (GST-mili-1)
Gene ID number55124
Swiss ProtQ8TC59
Tested Applications IF(IHC-P), IHC-P, IP, WB
Recommended dilutions0 ug), 5 ug/mL) IP (5, WB (0
Cross reactivityMouse
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts via the piRNA metabolic process, Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense, Besides their function in transposable elements repression, CD9 and STRA8 (By similarity), Directly binds piRNAs, GJA7, ITGA6, Indirectly modulate expression of genes such as PDGFRB, Inhibits tumor cell growth when repressed, Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females, Participates in a piRNA amplification loop, Plays an essential role in meiotic differentiation of spermatocytes, SLC2A1, THY1, The piRNA process acts upstream of known mediators of DNA methylation, When overexpressed, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660), germ cell differentiation and in self-renewal of spermatogonial stem cells, piRNAs are probably involved in other processes during meiosis such as translation regulation, which is essential for the germline integrity, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Cancer/testis antigen 80, HILI, PIWIL1L, PIWIL2, Piwi-like protein 2, mili, CT80
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetPIWIL2 (11C11) Monoclonal
Short namePIWIL2 (11C11) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative namepiwi-like 2 (Drosophila) (11C11) monoclonal (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Cytoplasm, PIWIL2 and IDBG-10698 and ENSG00000197181 and 55124, PIWIL2 and IDBG-634785 and ENSBTAG00000015835 and 537068, Piwil2 and IDBG-178442 and ENSMUSG00000033644 and 57746, piRNA binding, this GO :0000966 and RNA 5'-end processing and biological process this GO :0003676 and nucleic acid binding and molecular function this GO :0003729 and mRNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005844 and polysome and cellular component this GO :0007126 and meiotic nuclear division and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007283 and spermatogenesis and biological process this GO :0030718 and germ-line stem cell maintenance and biological process this GO :0031047 and gene silencing by RNA and biological process this GO :0033391 and chromatoid body and cellular component this GO :0034584 and piRNA binding and molecular function this GO :0034587 and piRNA metabolic process and biological process this GO :0043046 and DNA methylation involved in gamete generation and biological process this GO :0043186 and P granule and cellular component this GO :0045727 and positive regulation of translation and biological process this GO :0048477 and oogenesis and biological process this GO :0060903 and positive regulation of meiosis I and biological process this GO :0071546 and pi-body and cellular component, this GO :0003676: nucleic acid binding, this GO :0003676: nucleic acid binding and also this GO :0003729: mRNA binding and also this GO :0005515: protein binding and also this GO :0034584: piRNA binding, this GO :0003729: mRNA binding, this GO :0005515: protein binding, this GO :0034584: piRNA binding, piwi-like 2 (Drosophila)
Identity 17644
Gene PIWIL2
Long gene name piwi like RNA-mediated gene silencing 2
Synonyms gene name piwi-like 2 (Drosophila)
Synonyms HILI FLJ10351 Mili CT80
Synonyms name Hiwi-like cancer/testis antigen 80
Locus 8p21, 3
Discovery year 2002-04-26
GenBank acession AK001213
Entrez gene record 55124
Pubmed identfication 11279525 12906857
Classification Argonaute/PIWI family
Havana BLAST/BLAT OTTHUMG00000097767

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