PLK4 Antibody

PLK4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	PLK4 Primary Polyclonal Antibody
Also known as	PLK4 PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	PLK4
Specificity	This is a highly specific antibody against PLK4
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PLK4/STK18
Gene ID number	10733
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	Able to trigger procentriole formation on the surface of the parental centriole cylinder, Also involved in trophoblast differentiation by phosphorylating HAND1, CENPJ/CPAP, CEP135 and gamma-tubulin, CP110, Its central role in centriole replication suggests a posible role in tumorigenesis, Phosphorylates CDC25C and CHEK2/CHK2, When overexpressed, centrosome aberrations being frequently observed in tumors, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1, leading to the recruitment of centriole biogenesis proteins such as SASS6, Serine/threonine-protein kinase that plays a central role in centriole duplication
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	PLK-4, PLK4, PLK4_HUMAN, Polo like Kinase 4, Polo-like kinase 4, Protein serine/threonine kinase, SAK, STK 18, STK18, Serine/Threonine Kinase 18, Serine/threonine kinase, Serine/threonine protein kinase 18, Serine/threonine protein kinase PLK4, Serine/threonine protein kinase Sak, Serine/threonine-protein kinase 18, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SAK, Snk Akin Kinase, PLK 4
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	PLK4
Short name	PLK4 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	polo-like kinase 4 (Antibody to)
Alternative technique	antibodies
Alternative to gene target	PLK4 and IDBG-37545 and ENSG00000142731 and 10733, PLK4 and IDBG-630057 and ENSBTAG00000039552 and 514405, Plk4 and IDBG-141445 and ENSMUSG00000025758 and 20873, SAK and STK18, nuclei, this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005730 and nucleolus and cellular component this GO :0005813 and centrosome and cellular component this GO :0005814 and centriole and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007099 and centriole replication and biological process this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0042802: identical protein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042802: identical protein binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0032154 and cleavage furrow and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0046601 and positive regulation of centriole replication and biological process this GO :0060707 and trophoblast giant cell differentiation and biological process this GO :0098535 and de novo centriole assembly and biological process this GO :0098536 and deuterosome and cellular component, polo-like kinase 4
Identity	11397
Gene	PLK4
Long gene name	polo like kinase 4
Synonyms gene	STK18
Synonyms gene name	serine/threonine kinase 18 polo-like kinase 4 (Drosophila) polo-like kinase 4
Synonyms	Sak
Locus	4q28, 1
Discovery year	1998-12-09
GenBank acession	Y13115
Entrez gene record	10733
Havana BLAST/BLAT	OTTHUMG00000133301

PLK4 Antibody

PLK4 Antibody size: 0.1ml 263

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