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PRAS40 Antibody

PRAS40 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePRAS40 Primary Polyclonal Antibody
Also known asPRAS40 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPRAS40
SpecificityThis is a highly specific antibody against PRAS40
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range200-256/256
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PRAS40
Gene ID number84335
Swiss ProtQ96B36
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins, Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis, Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases, Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, Inhibits RHEB-GTP-dependent mTORC1 activation, May also play a role in nerve growth factor-mediated neuroprotection, Substrate for AKT1 phosphorylation, Within mTORC1, but can also be activated by AKT1-independent mechanisms, mTORC1 is activated in response to growth factors or amino acids, mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E), mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation, Subunit of mTORC1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 40 kDa proline-rich AKT substrate, AKT1S1, PRAS40, Proline-rich AKT1 substrate 1, Lobe
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPRAS40
Short namePRAS40 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePRAS40 (Antibody to)
Alternative techniqueantibodies
Identity 28426
Gene AKT1S1
Long gene name AKT1 substrate 1
Synonyms gene name AKT1 substrate 1 (proline-rich)
Synonyms PRAS40 MGC2865 Lobe
Synonyms name 40 kDa , proline-rich Akt substrate
Locus 19q13, 33
Discovery year 2004-03-04
GenBank acession BC022241
Entrez gene record 84335
Pubmed identfication 12524439
RefSeq identity NM_032375
Classification MTOR complex 1
Havana BLAST/BLAT OTTHUMG00000150246

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