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PRDX3 Antibody (Peroxiredoxin 3)

PRDX3 Antibody (Peroxiredoxin 3) size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPRDX3 (Peroxiredoxin 3)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0
Notes Titration of the PRDX3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis PRDX3 antibodyis to be used only for research purposes and not for diagnostics
Gene ID #10935
PurityAntigen affinity
Description Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1, Expression of Peroxiredoxin 3 is induced by MYC and is reduced in c-myc -/- cells, MER5, Results using mitochondria-specific fluorescent probes demonstrated that Peroxiredoxin 3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells, SP-22 or PRX3, The PRDX3 gene is mapped on 10q26, The deduced 256-amino acid human protein shares 86% amino acid sequence similarity with mouse, These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function, also known as AOP-1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23, is localized exclusively in mitochondria, 11, Peroxiredoxin 3
ImmunogenHuman partial recombinant protein (AA 110-256) was used as the immunogen for this PRDX3 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PRDX3 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPRDX3 (Peroxiredoxin 3)
Short namePRDX3 Antibody (Peroxiredoxin 3)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameperoxiredoxin 3 (Antibody to) (Peroxiredoxin 3)
Alternative techniqueantibodies
Alternative to gene target AOP-1 and AOP1 and HBC189 and MER5 and PRO1748 and prx-III and SP-22, Cytoplasm, PRDX3 and IDBG-640354 and ENSBTAG00000008731 and 281998, PRDX3 and IDBG-91076 and ENSG00000165672 and 10935, Prdx3 and IDBG-181859 and ENSMUSG00000024997 and 11757, peroxiredoxin activity, this GO :0001893 and maternal placenta development and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005769 and early endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006979 and response to oxidative stress and biological process this GO :0007005 and mitochondrion organization and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008379 and thioredoxin peroxidase activity and molecular function this GO :0008385 and IkappaB kinase complex and cellular component this GO :0008785 and alkyl hydroperoxide reductase activity and molecular function this GO :0016209 and antioxidant activity and molecular function this GO :0016491 and oxidoreductase activity and molecular function this GO :0018171 and peptidyl-cysteine oxidation and biological process this GO :0019900 and kinase binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030099 and myeloid cell differentiation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033673 and negative regulation of kinase activity and biological process this GO :0034599 and cellular response to oxidative stress and biological process this GO :0034614 and cellular response to reactive oxygen species and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042744 and hydrogen peroxide catabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043027 and cysteine-type endopeptidase inhibitor activity involved in apoptotic process and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0051920 and peroxiredoxin activity and molecular function this GO :0055114 and oxidation-reduction process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0008022: protein C-terminus binding and also this GO :0008379: thioredoxin peroxidase activity and also this GO :0008785: alkyl hydroperoxide reductase activity and also this GO :0016209: antioxidant activity and also this GO :0016491: oxidoreductase activity and also this GO :0019900: kinase binding and also this GO :0019901: protein kinase binding and also this GO :0042802: identical protein binding and also this GO :0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process and also this GO :0051920: peroxiredoxin activity, this GO :0008022: protein C-terminus binding, this GO :0008379: thioredoxin peroxidase activity, this GO :0008785: alkyl hydroperoxide reductase activity, this GO :0016209: antioxidant activity, this GO :0016491: oxidoreductase activity, this GO :0019900: kinase binding, this GO :0019901: protein kinase binding, this GO :0042802: identical protein binding, this GO :0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process, this GO :0051920: peroxiredoxin activity, peroxiredoxin 3
Identity 9354
Gene PRDX3
Long gene name peroxiredoxin 3
Synonyms gene AOP1
Synonyms gene name antioxidant protein 1
Synonyms MER5 AOP-1 SP-22
Locus 10q26, 11
Discovery year 1999-08-12
GenBank acession D49396
Entrez gene record 10935
Pubmed identfication 7733872 9363753
RefSeq identity NM_006793
Classification Peroxiredoxins
Havana BLAST/BLAT OTTHUMG00000019146

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