| Alternative name1 | Anti-PSEN1 Polyclonal Antibody |
| Alternative name2 | PSEN1 PAb |
| Alternative name3 | PSEN1 Polyclonal Antibody |
| Alternative name4 | PSEN1 |
| Alternative name5 | FAD, PS-1, PS1, S182, Presenilin 1: AD3 |
| Other names | PS1-CTF12, Presenilin-1, Presenilin-1 CTF subunit, Presenilin-1 CTF12, Protein S182Cleaved into the following 3 chains:Presenilin-1 NTF subunit, presenilin 1, presenilin-1, Presenilin-1 |
| Gene name | PSEN1 |
| Gene name synonims | N/A |
| Other gene names | AD3, AD3, FAD, PS-1, PS-1, PS1, PS1, PS1-CTF12, PSEN1, PSNL1, S182, PSEN1 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | IgG |
| Clone | Polyclonal antibody |
| Host organism | Rabbit |
| Species reactivity | Mouse, Rat, Human |
| Specificity and cross-reactivity | N/A |
| Purification method | Affinity Purification |
| Form/Appearance | N/A |
| Concentration | 1 miligram per 1 mililiter |
| Storage and shipping | 50% glycerol, Buffer: PBS with 0, Cycles of freeze/thaw should be avoided in order to retain the full activity, for long term storage, keep at -80 degrees Celsius, pH7, 02% sodium azide, 3, For short term storage keep at -20 degrees Celsius |
| Tested for: | Western Blot (WB) |
| Description | Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | PSEN1 |
| Short name | PSEN1 Polyclonal Antibody |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , antibodies against human proteins, antibodies for, each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Alternative name | presenilin 1 polyclonal (Antibody to) |
| Alternative technique | polyclonals |
| Alternative to gene target | AD3 and FAD and PS-1 and PS1 and S182, PSEN1 and IDBG-11235 and ENSG00000080815 and 5663, PSEN1 and IDBG-646832 and ENSBTAG00000011757 and 282705, Psen1 and IDBG-155522 and ENSMUSG00000019969 and 19164, cadherin binding, glutamatergic and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060075 and regulation of resting membrane potential and biological process this GO :0070588 and calcium ion transmembrane transport and biological process this GO :0070765 and gamma-secretase complex and cellular component this GO :2000059 and negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :2001234 and negative regulation of apoptotic signaling pathway and biological process, nuclei, this GO :0000045 and autophagic vacuole assembly and biological process this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000139 and this GO lgi membrane and cellular component this GO :0000186 and activation of MAPKK activity and biological process this GO :0000776 and kinetochore and cellular component this GO :0001568 and blood vessel development and biological process this GO :0001708 and cell fate specification and biological process this GO :0001756 and somitogenesis and biological process this GO :0001764 and neuron migration and biological process this GO :0001921 and positive regulation of receptor recycling and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0001947 and heart looping and biological process this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0002286 and T cell activation involved in immune response and biological process this GO :0002573 and myeloid leukocyte differentiation and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004190 and aspartic-type endopeptidase activity and molecular function this GO :0005262 and calcium channel activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005640 and nuclear outer membrane and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005790 and smooth endoplasmic reticulum and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005813 and centrosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006486 and protein glycosylation and biological process this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0006839 and mitochondrial transport and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006914 and autophagy and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007175 and negative regulation of epidermal growth factor-activated receptor activity and biological process this GO :0007176 and regulation of epidermal growth factor-activated receptor activity and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0007420 and brain development and biological process this GO :0007507 and heart development and biological process this GO :0007611 and learning or memory and biological process this GO :0007613 and memory and biological process this GO :0008013 and beta-catenin binding and molecular function this GO :0008233 and peptidase activity and molecular function this GO :0009791 and post-embryonic development and biological process this GO :0009986 and cell surface and cellular component this GO :0015031 and protein transport and biological process this GO :0015813 and L-glutamate transport and biological process this GO :0015871 and choline transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016080 and synaptic vesicle targeting and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0016485 and protein processing and biological process this GO :0021795 and cerebral cortex cell migration and biological process this GO :0021870 and Cajal-Retzius cell differentiation and biological process this GO :0021904 and dorsal/ventral neural tube patterning and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022008 and neurogenesis and biological process this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030018 and Z disc and cellular component this GO :0030165 and PDZ domain binding and molecular function this GO :0030182 and neuron differentiation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0030426 and growth cone and cellular component this GO :0030900 and forebrain development and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031594 and neuromuscular junction and cellular component this GO :0031965 and nuclear membrane and cellular component this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0032469 and endoplasmic reticulum calcium ion homeostasis and biological process this GO :0034205 and beta-amyloid formation and biological process this GO :0035253 and ciliary rootlet and cellular component this GO :0035282 and segmentation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040011 and locomotion and biological process this GO :0042325 and regulation of phosphorylation and biological process this GO :0042640 and anagen and biological process this GO :0042987 and amyloid precursor protein catabolic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043198 and dendritic shaft and cellular component this GO :0043227 and membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043589 and skin morphogenesis and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0045121 and membrane raft and cellular component this GO :0045296 and cadherin binding and molecular function this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0048167 and regulation of synaptic plasticity and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048538 and thymus development and biological process this GO :0048666 and neuron development and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048854 and brain morphogenesis and biological process this GO :0050435 and beta-amyloid metabolic process and biological process this GO :0050673 and epithelial cell proliferation and biological process this GO :0050771 and negative regulation of axonogenesis and biological process this GO :0050820 and positive regulation of coagulation and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0051444 and negative regulation of ubiquitin-protein transferase activity and biological process this GO :0051563 and smooth endoplasmic reticulum calcium ion homeostasis and biological process this GO :0051604 and protein maturation and biological process this GO :0051966 and regulation of synaptic transmission, this GO :0004175: endopeptidase activity, this GO :0004175: endopeptidase activity and also this GO :0004190: aspartic-type endopeptidase activity and also this GO :0005262: calcium channel activity and also this GO :0005515: protein binding and also this GO :0008013: beta-catenin binding and also this GO :0008233: peptidase activity and also this GO :0030165: PDZ domain binding and also this GO :0045296: cadherin binding, this GO :0004190: aspartic-type endopeptidase activity, this GO :0005262: calcium channel activity, this GO :0005515: protein binding, this GO :0008013: beta-catenin binding, this GO :0008233: peptidase activity, this GO :0030165: PDZ domain binding, this GO :0045296: cadherin binding, presenilin 1 |
| Identity | 9508 |
| Gene | PSEN1 |
| Long gene name | presenilin 1 |
| Synonyms gene | AD3 |
| Synonyms gene name | Alzheimer disease 3 |
| Synonyms | FAD S182 PS1 |
| Locus | 14q24, 2 |
| Discovery year | 1992-11-05 |
| GenBank acession | AJ008005 |
| Entrez gene record | 5663 |
| Pubmed identfication | 1411576 |
| RefSeq identity | NM_000021 |
| Havana BLAST/BLAT | OTTHUMG00000141279 |
| Locus Specific Databases | Alzheimer Disease &, Frontotemporal Dementia Mutation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_224 |
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