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RIP2 Antibody

RIP2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRIP2 Primary Polyclonal Antibody
Also known asRIP2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRIP2
SpecificityThis is a highly specific antibody against RIP2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range450-500/540
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RIP2
Gene ID number8767
Swiss ProtO43353
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen BIRC2 and BIRC3, Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, NOD1 and NOD2 are activated, Once recruited, Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB, Upon stimulation by bacterial peptidoglycans, growth control, oligomerize and recruit RIPK2 through CARD-CARD domains, or protection against apoptosis, Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARD3, CARDIAK, GIG30, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, RIPK2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2, Tyrosine-protein kinase RIPK2, UNQ277/PRO314/PRO34092, CCK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRIP2
Short nameRIP2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRIP2 (Antibody to)
Alternative techniqueantibodies
Identity 30322
Gene ARHGEF28
Long gene name Rho guanine nucleotide exchange factor 28
Synonyms gene name Rho guanine nucleotide exchange factor (GEF) 28
Synonyms RGNEF p190RhoGEF RIP2
Locus 5q13, 2
Discovery year 2012-08-08
Entrez gene record 64283
Pubmed identfication 9199174 11058585
Havana BLAST/BLAT OTTHUMG00000162454

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