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S100 beta Antibody

S100 beta Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenS100 beta
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the S100 beta antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis S100 beta antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P04271
PurityAntigen affinity
Description Addition of the disulfide-bonded dimeric form of S100 beta to primary neuronal and glial cultures and established cell lines induces axonal extension and alterations in astrocyte proliferation and phenotype, Reeves et al, S100 beta is a calcium-binding protein that is expressed at high levels in brain primarily by astrocytes, S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, S100B is a glial-derived protein that is a well-established biomarker for severity of neurological injury and prognosis for recovery, They found that both astrocytosis and neurite proliferation occurred in transgenic mice expressing elevated levels of S100b, They suggested that these transgenic mice represent a useful model for studies of the role of S100B in glial-neuronal interactions in normal development and function of the brain and for analyzing the significance of elevated levels of the protein in Down syndrome and Alzheimer disease, but evidence that S100 beta exerts the same effects in vivo has not been presented, however, this gene is located at 21q22, (1994) demonstrated that the same effects of the S100B protein are exerted in vivo, 3, S100 calcium binding protein B or S100B is a protein of the S-100 protein family
Immunogen mouse and rat), An amino acid sequence from the C-terminus of human S100 beta (DGDGECDFQEFMAFV) was used as the immunogen for this S100 beta antibody (100% homologous in human
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the S100 beta antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetS100 beta
Short nameS100 beta Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameS100 b (Antibody to)
Alternative techniqueantibodies
Identity 10500
Gene S100B
Long gene name S100 calcium binding protein B
Synonyms gene name S100 calcium binding protein, beta (neural)
Synonyms S100beta
Locus 21q22, 3
Discovery year 1988-06-27
GenBank acession M59488
Entrez gene record 6285
Pubmed identfication 2394738 1998503
RefSeq identity NM_006272
Classification S100 calcium binding proteins EF-hand domain containing
Havana BLAST/BLAT OTTHUMG00000090715

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