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SHC Antibody

SHC Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSHC Primary Polyclonal Antibody
Also known asSHC PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSHC
SpecificityThis is a highly specific antibody against SHC
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range480-520/583
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SHC
Gene ID number6464
Swiss ProtP29353
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Isoform p46Shc and isoform p52Shc, Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems, Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, Isoform p66Shc does not mediate Ras activation, Participates in a signaling cascade initiated by activated KIT and KITLG/SCF, Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, The expression of isoform p66Shc has been correlated with life span (By similarity), and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals, cytochrome c release and apoptosis, once phosphorylated, Signaling adapter that couples activated growth factor receptors to signaling pathways
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names SH2 domain protein C1, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, SHC1, SHCA, Src homology 2 domain-containing-transforming protein C1, SHC
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSHC
Short nameSHC Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSHC (Antibody to)
Alternative techniqueantibodies
Identity 10840
Gene SHC1
Long gene name SHC adaptor protein 1
Synonyms gene SHC
Synonyms gene name SHC (Src homology 2 domain-containing) transforming protein 1
Synonyms p66 ShcA
Locus 1q21, 3
Discovery year 1993-02-17
GenBank acession U73377
Entrez gene record 6464
Pubmed identfication 1623525
RefSeq identity NM_183001
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000037295

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