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SHC (Tyr427) Antibody, Cy7 Conjugated

SHC (Tyr427) Antibody, Cy7 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, SHC (Tyr427) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSHC Tyr427
SpecificityThis is a highly specific antibody against SHC Tyr427
ModificationPhosphorylation
Modification siteTyr427
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range405-455/583
Subcellular location Mitochondrion, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human SHC around the phosphorylation site of Tyr427
Gene ID number6464
Swiss ProtP29353
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Isoform p46Shc and isoform p52Shc, Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems, Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, Isoform p66Shc does not mediate Ras activation, Participates in a signaling cascade initiated by activated KIT and KITLG/SCF, Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, The expression of isoform p66Shc has been correlated with life span (By similarity), and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals, cytochrome c release and apoptosis, once phosphorylated, Signaling adapter that couples activated growth factor receptors to signaling pathways
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms p66 ShcA
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetSHC (Tyr427) Conjugated
Short name Conjugated, SHC (Tyr427) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, SHC (Tyr427) (Antibody to)
Alternative techniqueantibodies
Identity 10840
Gene SHC1
Long gene name SHC adaptor protein 1
Synonyms gene SHC
Synonyms gene name SHC (Src homology 2 domain-containing) transforming protein 1
Locus 1q21, 3
Discovery year 1993-02-17
GenBank acession U73377
Entrez gene record 6464
Pubmed identfication 1623525
RefSeq identity NM_183001
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000037295

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