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SMN1 Antibody, ALEXA FLUOR 350

SMN1 Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, SMN1 Polyclonal Antibody
Also known asAnti-SMN1 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSMN1
SpecificityThis is a highly specific antibody against SMN1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range60-95/294
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SMN1
Gene ID Number6606
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen 2a, 2b, Four transcript variants encoding distinct isoforms have been described, It is thought that gene conversion events may involve the two genes, Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, The critical sequence difference between the two genes is a single nucleotide in exon 7, The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus, The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region, The telomeric and centromeric copies of this gene are nearly identical and encode the same protein, This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions, This gene may be a modifier of disease caused by mutation in the telomeric copy, This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, While mutations in the telomeric copy are associated with spinal muscular atrophy, Within the nucleus, and 3-8, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, do not lead to disease, leading to varying copy numbers of each gene, mutations in this gene, such as hnRNP U protein and the small nucleolar RNA binding protein, the centromeric copy, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs), which is thought to be an exon splice enhancer, SMN1 is part of a 500 kb inverted duplication on chromosome 5q13
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetSMN1
Short nameSMN1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, SMN1 (Antibody to)
Alternative techniqueantibodies
Identity 11117
Gene SMN1
Long gene name survival of motor neuron 1, telomeric
Synonyms gene SMA@ SMA
Synonyms gene name Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease
Synonyms name gemin-1 tudor domain containing 16A
Locus 5q13, 2
Discovery year 1996-12-12
GenBank acession U18423
Entrez gene record 6606
Pubmed identfication 7813012
RefSeq identity NM_000344
Classification Tudor domain containing
Havana BLAST/BLAT OTTHUMG00000099361
Locus Specific Databases SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676

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