| Long name | STXBP1(Ser515) Primary Polyclonal Antibody |
| Also known as | STXBP1(Ser515) PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | STXBP1 Ser515 |
| Specificity | This is a highly specific antibody against STXBP1 Ser515 |
| Modification(s) | Phosphorylation |
| Modification site(s) | Ser515 |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from human STXBP1 around the phosphorylation site of Ser515 |
| Gene ID number | 6812 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | 2, It is essential for neurotransmission and binds syntaxin, It may play a role in determining the specificity of intracellular fusion reactions, Munc18 can interact with syntaxins 1, Munc18-1 has been shown to be primarily expressed in brain, Mutations in Munc18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect, Two Munc18 isoforms have recently been identified, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio, and 3 but not syntaxin 4, possibly through interaction with GTP binding proteins, while Munc18-2 is expressed in most tissues, Munc18 may participate in the regulation of synaptic vesicle docking and fusion |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | FLJ37475, Munc 18, Munc 18 1, Munc 18a, Munc18 1, Munc18a, N Sec1, N-Sec1, NSec1, Neuronal SEC1, Protein unc-18 homolog 1, Protein unc-18 homolog A, RBSEC1, Rb sec1, STX BP1, STXB1_HUMAN, STXBP 1, STXBP1, Syntaxin binding protein 1, Syntaxin-binding protein 1, UNC 18, UNC18, Unc 18 1, Unc 18 homolog, Unc 18A, Unc-18A, Unc18 1, Unc18 homolog, Unc18-1, Unc18A, hUNC 18, hUNC18, p67, Stxbp1phospho S515 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | STXBP1(Ser515) |
| Short name | STXBP1(Ser515) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | syntaxin binding protein 1(Ser515) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | GABAergic and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045921 and positive regulation of exocytosis and biological process this GO :0045956 and positive regulation of calcium ion-dependent exocytosis and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0050796 and regulation of insulin secretion and biological process this GO :0050821 and protein stabilization and biological process this GO :0060292 and long term synaptic depression and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070527 and platelet aggregation and biological process, MUNC18-1 and NSEC1 and P67 and RBSEC1 and UNC18, Plasma membranes, STXBP1 and IDBG-638972 and ENSBTAG00000003525 and 282378, STXBP1 and IDBG-86143 and ENSG00000136854 and 6812, Stxbp1 and IDBG-161623 and ENSMUSG00000026797 and 20910, protein N-terminus binding, this GO :0000149 and SNARE binding and molecular function this GO :0002576 and platelet degranulation and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006112 and energy reserve metabolic process and biological process this GO :0006887 and exocytosis and biological process this GO :0006904 and vesicle docking involved in exocytosis and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007269 and neurotransmitter secretion and biological process this GO :0007274 and neuromuscular synaptic transmission and biological process this GO :0007412 and axon target recognition and biological process this GO :0010807 and regulation of synaptic vesicle priming and biological process this GO :0014047 and glutamate secretion and biological process this GO :0015031 and protein transport and biological process this GO :0016188 and synaptic vesicle maturation and biological process this GO :0016192 and vesicle-mediated transport and biological process this GO :0017075 and syntaxin-1 binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0019905 and syntaxin binding and molecular function this GO :0031091 and platelet alpha granule and cellular component this GO :0032229 and negative regulation of synaptic transmission, this GO :0000149: SNARE binding, this GO :0000149: SNARE binding and also this GO :0005515: protein binding and also this GO :0017075: syntaxin-1 binding and also this GO :0019901: protein kinase binding and also this GO :0019904: protein domain specific binding and also this GO :0019905: syntaxin binding and also this GO :0042802: identical protein binding and also this GO :0044822: poly(A) RNA binding and also this GO :0047485: protein N-terminus binding, this GO :0005515: protein binding, this GO :0017075: syntaxin-1 binding, this GO :0019901: protein kinase binding, this GO :0019904: protein domain specific binding, this GO :0019905: syntaxin binding, this GO :0042802: identical protein binding, this GO :0044822: poly(A) RNA binding, this GO :0047485: protein N-terminus binding, syntaxin binding protein 1 |
| Identity | 11444 |
| Gene | STXBP1 |
| Long gene name | syntaxin binding protein 1 |
| Synonyms | hUNC18 MUNC18-1 UNC18 rbSec1 |
| Synonyms name | syntaxin-binding protein 1 |
| Locus | 9q34, 11 |
| Discovery year | 1996-12-27 |
| GenBank acession | AF004563 |
| Entrez gene record | 6812 |
| Pubmed identfication | 9545644 |
| RefSeq identity | NM_003165 |
| Havana BLAST/BLAT | OTTHUMG00000020713 |
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