| Long name | Biotin Conjugated, TCF7L2 Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Biotinylated |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | TCF7L2 |
| Specificity | This is a highly specific antibody against TCF7L2 |
| Modification | Unmodified |
| Modification site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen_range | 410-460/619 |
| Subcellular location | Nucleus |
| Source | KLH conjugated synthetic peptide derived from human TCF7L2 |
| Gene ID number | 6934 |
| Swiss Prot | Q9NQB0 |
| Tested applications | IHC-P, WB |
| Recommended dilutions | IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity | Mouse, Rat, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1, Acts as repressor in the absence of CTNNB1, Expression of dominant-negative mutants results in cell-cycle arrest in G1, Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine, TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1, and as activator in its presence, Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | N/A |
| Synonyms | TCF-4 |
| Properties | Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TCF7L2 Conjugated |
| Short name | Conjugated, TCF7L2 Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | Biotin |
| Alternative name | HMG-box) (Antibody to), biotinilated coupled, transcription factor 7-like 2 (T-cellular specific |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007420 and brain development and biological process this GO :0008013 and beta-catenin binding and molecular function this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0009749 and response to glucose and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010867 and positive regulation of triglyceride biosynthetic process and biological process this GO :0010909 and positive regulation of heparan sulfate proteoglycan biosynthetic process and biological process this GO :0014003 and oli this GO dendrocyte development and biological process this GO :0016055 and Wnt signaling pathway and biological process this GO :0016605 and PML body and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0021915 and neural tube development and biological process this GO :0021983 and pituitary gland development and biological process this GO :0030282 and bone mineralization and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0030538 and embryonic genitalia morphogenesis and biological process this GO :0031016 and pancreas development and biological process this GO :0031641 and regulation of myelination and biological process this GO :0032024 and positive regulation of insulin secretion and biological process this GO :0032092 and positive regulation of protein binding and biological process this GO :0032252 and secretory granule localization and biological process this GO :0032350 and regulation of hormone metabolic process and biological process this GO :0032993 and protein-DNA complex and cellular component this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035257 and nuclear hormone receptor binding and molecular function this GO :0035264 and multicellular organism growth and biological process this GO :0035411 and catenin import into nucleus and biological process this GO :0040037 and negative regulation of fibroblast growth factor receptor signaling pathway and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0043570 and maintenance of DNA repeat elements and biological process this GO :0043588 and skin development and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0044334 and canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition and biological process this GO :0045295 and gamma-catenin binding and molecular function this GO :0045444 and fat cell differentiation and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045722 and positive regulation of gluconeogenesis and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046621 and negative regulation of organ growth and biological process this GO :0046827 and positive regulation of protein export from nucleus and biological process this GO :0046889 and positive regulation of lipid biosynthetic process and biological process this GO :0048557 and embryonic digestive tract morphogenesis and biological process this GO :0048619 and embryonic hindgut morphogenesis and biological process this GO :0048625 and myoblast fate commitment and biological process this GO :0048641 and regulation of skeletal muscle tissue development and biological process this GO :0048660 and regulation of smooth muscle cell proliferation and biological process this GO :0048699 and generation of neurons and biological process this GO :0048713 and regulation of oli this GO dendrocyte differentiation and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060325 and face morphogenesis and biological process this GO :0061178 and regulation of insulin secretion involved in cellular response to glucose stimulus and biological process this GO :0070016 and armadillo repeat domain binding and molecular function this GO :0070369 and beta-catenin-TCF7L2 complex and cellular component this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :1901142 and insulin metabolic process and biological process this GO :2000675 and negative regulation of type B pancreatic cell apoptotic process and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process, HMG-box), TCF-4 and TCF4, TCF7L2 and IDBG-89861 and ENSG00000148737 and 6934, TCFL2 and IDBG-639856 and ENSBTAG00000021574 and 540481, Tcf7l2 and IDBG-177837 and ENSMUSG00000024985 and 21416, armadillo repeat domain binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0001568 and blood vessel development and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005977 and glycogen metabolic process and biological process this GO :0006006 and glucose metabolic process and biological process this GO :0006351 and transcription, this GO :0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0001103: RNA polymerase II repressing transcription factor binding and also this GO :0003682: chromatin binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding and also this GO :0008013: beta-catenin binding and also this GO :0008134: transcription factor binding and also this GO :0019901: protein kinase binding and also this GO :0035257: nuclear hormone receptor binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0045295: gamma-catenin binding and also this GO :0070016: armadillo repeat domain binding, this GO :0001103: RNA polymerase II repressing transcription factor binding, this GO :0003682: chromatin binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, this GO :0008013: beta-catenin binding, this GO :0008134: transcription factor binding, this GO :0019901: protein kinase binding, this GO :0035257: nuclear hormone receptor binding, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0045295: gamma-catenin binding, this GO :0070016: armadillo repeat domain binding, transcription factor 7-like 2 (T-cell specific |
| Identity | 11641 |
| Gene | TCF7L2 |
| Long gene name | transcription factor 7 like 2 |
| Synonyms gene | TCF4 |
| Synonyms gene name | HMG-box) , transcription factor 7-like 2 (T-cell specific |
| Locus | 10q25, 2-q25, 3 |
| Discovery year | 1998-01-20 |
| GenBank acession | X62871 |
| Entrez gene record | 6934 |
| Pubmed identfication | 1741298 |
| RefSeq identity | NM_030756 |
| Havana BLAST/BLAT | OTTHUMG00000019070 |
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