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TERT(Ser1125) Antibody

TERT(Ser1125) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTERT(Ser1125) Primary Polyclonal Antibody
Also known asTERT(Ser1125) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTERT Ser1125
SpecificityThis is a highly specific antibody against TERT Ser1125
Modification(s)Phosphorylation
Modification site(s)Ser1125
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human TERT around the phosphorylation site of Ser1125
Gene ID number7015
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen During the past year, Ever since the discovery that telomeres are short in cancer cells and telomerase is activated in immortal cells, Identification of new telomere proteins has led to a better understanding of vertebrate telomere structure and function, It elongates telomeres, It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme, Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, Studies of yeast telomeres have revealed an unexpected role for the non-homologous end-joining machinery in telomere maintenance and have provided the first definitive evidence that telomeres play a critical role in meiosis, TERT, Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization, and that TERT cooperates with HPV E7 in cell immortalization, major advances have been made in understanding the link between telomerase expression and cell immortality, telomerase has been associated with oncogenes, Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names EST2, TCS1, TERT, TERTphospho S1125, TP2, TRT, Telomerase Catalytic Subunit, Telomerase associated protein 2, Telomere Reverse Transcriptase, hEST2, p-TERTSer1125
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTERT(Ser1125)
Short nameTERT(Ser1125) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nametelomerase reverse transcriptase(Ser1125) (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BT, CMM9 and DKCA2 and DKCB4 and EST2 and hEST2 and hTRT and PFBMFT1 and TCS1 and TP2 and TRT, TERT and IDBG-10998 and ENSG00000164362 and 7015, Tert and IDBG-165912 and ENSMUSG00000021611 and 21752, nuclei, telomeric RNA binding, telomeric region and cellular component this GO :0000783 and nuclear telomere cap complex and cellular component this GO :0003720 and telomerase activity and molecular function this GO :0003721 and telomeric template RNA reverse transcriptase activity and molecular function this GO :0003964 and RNA-directed DNA polymerase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005697 and telomerase holoenzyme complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007004 and telomere maintenance via telomerase and biological process this GO :0016605 and PML body and cellular component this GO :0022616 and DNA strand elongation and biological process this GO :0032203 and telomere formation via telomerase and biological process this GO :0042162 and telomeric DNA binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0070034 and telomeric RNA binding and molecular function this GO :0090399 and replicative senescence and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0000723 and telomere maintenance and biological process this GO :0000781 and chromosome, this GO :0003720: telomerase activity, this GO :0003720: telomerase activity and also this GO :0003721: telomeric template RNA reverse transcriptase activity and also this GO :0003964: RNA-directed DNA polymerase activity and also this GO :0005515: protein binding and also this GO :0042162: telomeric DNA binding and also this GO :0042803: protein homodimerization activity and also this GO :0046872: metal ion binding and also this GO :0070034: telomeric RNA binding, this GO :0003721: telomeric template RNA reverse transcriptase activity, this GO :0003964: RNA-directed DNA polymerase activity, this GO :0005515: protein binding, this GO :0042162: telomeric DNA binding, this GO :0042803: protein homodimerization activity, this GO :0046872: metal ion binding, this GO :0070034: telomeric RNA binding, 60929 and IDBG-632169 and ENSBTAG00000012567 and 518884, telomerase reverse transcriptase
Identity 11730
Gene TERT
Long gene name telomerase reverse transcriptase
Synonyms TRT TP2 TCS1 hEST2 EST2
Locus 5p15, 33
Discovery year 1998-01-21
GenBank acession AF015950
Pubmed identfication 9252327
Havana BLAST/BLAT OTTHUMG00000090357
Locus Specific Databases LRG_343

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