| Long name | TLR3 Primary Polyclonal Antibody |
| Also known as | TLR3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | TLR3 |
| Specificity | This is a highly specific antibody against TLR3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 860-900/905 |
| Subcellular location | Cytoplasm |
| Source | KLH conjugated synthetic peptide derived from mouse TLR3 |
| Gene ID number | 142980 |
| Swiss Prot | Q99MB1 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Rat, Mouse |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts via the adapter TRIF/TICAM1, IRF3 nuclear translocation, TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms, a sign of viral infection, cytokine secretion and the inflammatory response (By similarity), leading to NF-kappa-B activation, Key component of innate and adaptive immunity |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CD283, Tlr3, Toll-like receptor 3, AI957183 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | TLR3 |
| Short name | TLR3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | toll-like receptor 3 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | CD283 and IIAE2, Cell surfaces, TLR3 and IDBG-47294 and ENSG00000164342 and 7098, TLR3 and IDBG-628571 and ENSBTAG00000008682 and 281535, Tlr3 and IDBG-152685 and ENSMUSG00000031639 and 142980, protein binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0001774 and microglial cell activation and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002282 and microglial cell activation involved in immune response and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003725 and double-stranded RNA binding and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006952 and defense response and biological process this GO :0006954 and inflammatory response and biological process this GO :0006972 and hyperosmotic response and biological process this GO :0007165 and signal transduction and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0007252 and I-kappaB phosphorylation and biological process this GO :0008584 and male this GO nad development and biological process this GO :0009597 and detection of virus and biological process this GO :0009615 and response to virus and biological process this GO :0009986 and cell surface and cellular component this GO :0010008 and endosome membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0032755 and positive regulation of interleukin-6 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0034123 and positive regulation of toll-like receptor signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034346 and positive regulation of type III interferon production and biological process this GO :0035458 and cellular response to interferon-beta and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035690 and cellular response to drug and biological process this GO :0036020 and endolysosome membrane and cellular component this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043330 and response to exogenous dsRNA and biological process this GO :0043331 and response to dsRNA and biological process this GO :0045078 and positive regulation of interferon-gamma biosynthetic process and biological process this GO :0045080 and positive regulation of chemokine biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045356 and positive regulation of interferon-alpha biosynthetic process and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045671 and negative regulation of osteoclast differentiation and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051607 and defense response to virus and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071346 and cellular response to interferon-gamma and biological process this GO :0071359 and cellular response to dsRNA and biological process this GO :0071360 and cellular response to exogenous dsRNA and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097527 and necroptotic signaling pathway and biological process, this GO :0003725: double-stranded RNA binding, this GO :0003725: double-stranded RNA binding and also this GO :0004872: receptor activity and also this GO :0004888: transmembrane signaling receptor activity and also this GO :0005515: protein binding, this GO :0004872: receptor activity, this GO :0004888: transmembrane signaling receptor activity, this GO :0005515: protein binding, toll-like receptor 3 |
| Identity | 11849 |
| Gene | TLR3 |
| Long gene name | toll like receptor 3 |
| Synonyms gene name | toll-like receptor 3 |
| Synonyms | CD283 |
| Locus | 4q35, 1 |
| Discovery year | 1998-06-25 |
| GenBank acession | U88879 |
| Entrez gene record | 7098 |
| Pubmed identfication | 9435236 |
| Classification | CD molecules Toll like receptors |
| Havana BLAST/BLAT | OTTHUMG00000160345 |
| Locus Specific Databases | TLR3base: Mutation registry for Influenza-associated encephalopathy LRG_117 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue