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Twinkle/ATXN8 Antibody, FITC Conjugated

Twinkle/ATXN8 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, Twinkle/ATXN8 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenTwinkle/ATXN8
SpecificityThis is a highly specific antibody against Twinkle/ATXN8
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human Twinkle/ATXN8
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Colocalized with mtDNA (mitochondrial DNA) in mitochondrial nucleoids, Defects in the gene encoding Twinkle are the cause of two conditions: progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant 3 (PEOA3) and sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), PEOA3, PEOA3 is characterized by ptosis and weak muscles, SANDO or TWINL, Twinkle is expressed at high levels in testis, Twinkle is important in the metabolism and maintenance of mtDNA, also known as PEO1 (Progressive external ophthalmoplegia 1 protein), dysarthria and sensory ataxic neuropathies, is a mitochondrial protein that functions as a 5â, nucleotide-dependent DNA helicase, pancreas and skeletal muscle and exists as three isoforms due to alternative splicing events, playing a crucial role in the regulation of mtDNA copy numbers, while SANDO is characterized by ophthalmoparesis, &euro, &euro, &trade, &trade, -3â, Twinkle
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetTwinkle/ATXN8 Conjugated
Short name FITC Conjugated, Twinkle/ATXN8 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, Twinkle/ATXN8 (Antibody to)
Alternative techniqueantibodies
Identity 32925
Gene ATXN8
Long gene name ataxin 8
Locus 13q21, 33
Discovery year 2006-07-18
GenBank acession DQ641254
Entrez gene record 724066
Pubmed identfication 16804541
Classification Ataxins

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