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Tyrosinase

Tyrosinase size: 100ug 354

Supplier MBS MONO
Price 354
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asTyrosinase
Other names LB24-AB, LB24-AB, Monophenol monooxygenase, SK29-AB, SK29-AB, Tumor rejection antigen AB, Tyrosinase, monophenol monooxygenase, oculocutaneous albinism IA, tumor rejection antigen AB, tyrosinase, tyrosinase, tyrosinase
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameTYR
Gene name synonimsN/A
Other gene names ATN, CMM8, N/A, OCA1, OCA1A, OCAIA, SHEP3, TYR, TYR
ClonalityMonoclonal
Immunoglobulin isotype kappa, IgG2a
CloneT311
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity Mutations of the tyrosinase gene occur in various forms of albinism, Occasionally a minor band at 55kDa is also detected, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants, TRP-1/gp75, This MAb is a useful marker for melanocytes and melanomas, This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, This particular antibody might cross react with speacies outside of the listed ones, Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients, and the subsequent oxidation of dopa to dopaquinone, identified as tyrosinase, the hydroxylation of tyrosine to L-3, 4-dihydroxy-phenylalanine (dopa), Recognizes a cluster of proteins between 70-80kDa
Purification methodN/A
Form/AppearanceN/A
ConcentrationN/A
Storage and shipping Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C
Tested applications: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA)
Gene targetTyrosinase
Short nameTyrosinase
Alternative nameTyrosinase
Identity 12442
Gene TYR
Long gene name tyrosinase
Synonyms OCAIA OCA1A OCA1
Synonyms name oculocutaneous albinism IA
Locus 11q14, 3
Discovery year 1988-08-16
GenBank acession M27160
Entrez gene record 7299
RefSeq identity NM_000372
Havana BLAST/BLAT OTTHUMG00000167294
Locus Specific Databases Albinism Database Mutations of the Tyrosinase Gene

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