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UCH37 Antibody

UCH37 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenUCH37
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the UCH37 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis UCH37 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q9Y5K5
PurityPurified
Description (1989) purified the predominant isozyme, All 4 were thiol proteases and had high-affinity binding sites for ubiquitin, By screening a human B-cell expression library with the antibodies, Mayer and Wilkinson (1989) identified 4 distinct UCH activities from bovine thymus, Sequence comparisons revealed that the sequence of the predicted 230-amino acid human UCHL3 protein is 54% identical to that of UCHL1, There are 2 distinct families of DUBs, UCHL3, Ubiquitin C-terminal hydrolysis is catalyzed by deubiquitinating (DUB) enzymes and is necessary for several functions, Wilkinson et al, and raised antibodies against it, including liberation of monomeric ubiquitin from the precursors encoded by ubiquitin genes and recycling of ubiquitin monomers, the authors isolated cDNAs encoding human UCHL3, ubiquitin-specific proteases (UBPs) and ubiquitin C-terminal hydrolases (UCHs), Covalent attachment of the C-terminus of ubiquitin to cellular proteins plays a role in a variety of cellular processes
ImmunogenA portion of amino acids 56-87 from the human protein was used as the immunogen for this UCH37 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the UCH37 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetUCH37
Short nameUCH37 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameUCH37 (Antibody to)
Alternative techniqueantibodies
Identity 19678
Gene UCHL5
Long gene name ubiquitin C-terminal hydrolase L5
Synonyms gene name ubiquitin carboxyl-terminal hydrolase L5
Synonyms UCH37 CGI-70 INO80R
Synonyms name INO80 complex subunit R
Locus 1q31, 2
Discovery year 2002-11-11
Entrez gene record 51377
Pubmed identfication 10810093 16027725
RefSeq identity NM_015984
Classification Ubiquitin C-terminal hydrolases INO80 complex
Havana BLAST/BLAT OTTHUMG00000035561

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