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VHL Antibody

VHL Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenVHL
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, FACS, IF, IHC, WB
Recommended dilutionsFlow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the VHL antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis VHL antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P40337
PurityPurified
Description A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome, RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein, The protein is a component of the protein complex that includes elongin B, This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), and cullin-2, and possesses ubiquitin ligase E3 activity, elongin C, which is a transcription factor that plays a central role in the regulation of gene expression by oxygen, Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors
ImmunogenA portion of amino acids 43-71 from the human protein was used as the immunogen for this VHL antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the VHL antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetVHL
Short nameVHL Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name E3 ubiquitin protein ligase (Antibody to), von Hippel-Lindau tumor suppressor
Alternative techniqueantibodies
Alternative to gene target BT, DNA-templated and biological process this GO :0006508 and proteolysis and biological process this GO :0006950 and response to stress and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0019899 and enzyme binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045111 and intermediate filament cytoskeleton and cellular component this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0050821 and protein stabilization and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0061428 and negative regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0071456 and cellular response to hypoxia and biological process, E3 ubiquitin protein ligase, HRCA1 and pVHL and RCA1 and VHL1, VHL and IDBG-17819 and ENSG00000134086 and 7428, Vhl and IDBG-178105 and ENSMUSG00000033933 and 22346, enzyme binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0019899: enzyme binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0019899: enzyme binding, 79817 and IDBG-644624 and ENSBTAG00000016101 and 540957, von Hippel-Lindau tumor suppressor
Identity 12687
Gene VHL
Long gene name von Hippel-Lindau tumor suppressor
Synonyms gene name E3 ubiquitin protein ligase , von Hippel-Lindau syndrome von Hippel-Lindau tumor suppressor
Synonyms VHL1
Locus 3p25, 3
Discovery year 1986-01-01
GenBank acession L15409
Entrez gene record 7428
Pubmed identfication 9671762
RefSeq identity NM_000551
Havana BLAST/BLAT OTTHUMG00000128668
Locus Specific Databases UMD Locus Specific Databases LRG_322

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