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APC11 Antibody

APC11 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAPC11 Primary Polyclonal Antibody
Also known asAPC11 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAPC11
SpecificityThis is a highly specific antibody against APC11
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APC11
Gene ID number51529
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APC, APC is phosphorylated, APC is under tight control by a number of regulatory factors, APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2), CDC20 and CDH1 directly bind to APC and activates APCâ, CDH1 and MAD2, In addition, In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, Specifically, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk), including CDC20, or cyclosome, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis, thus preventing APC activation, &euro, &trade, Comprising more than ten subunits, s cyclin-ubiquitination activity
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ANAPC11, APC11, APC11 anaphase promoting complex subunit 11 homolog, APC11 anaphase promoting complex subunit 11 homolog yeast, APC11_HUMAN, Anaphase promoting complex subunit 11, Anaphase promoting complex subunit 11 homolog, Anaphase promoting complex subunit 11 homolog yeast, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p, Apc11p, Cyclosome subunit 11, HSPC 214, HSPC214, Hepatocellular carcinoma associated RING finger protein, Hepatocellular carcinoma-associated RING finger protein, MGC882, Yeast APC 11 homolog, Yeast APC11 homolog, ANAPC 11
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAPC11
Short nameAPC11 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAPC11 (Antibody to)
Alternative techniqueantibodies
Identity 14452
Gene ANAPC11
Long gene name anaphase promoting complex subunit 11
Synonyms gene name anaphase promoting complex subunit 11 (yeast APC11 homolog)
Synonyms HSPC214 APC11 Apc11p MGC882
Locus 17q25, 3
Discovery year 2001-03-08
GenBank acession AF247565
Entrez gene record 51529
Pubmed identfication 10922056
RefSeq identity NM_016476
Classification Anaphase promoting complex
Havana BLAST/BLAT OTTHUMG00000177982

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