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Beta catenin Antibody

Beta catenin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameBeta catenin Primary Polyclonal Antibody
Also known asBeta catenin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBeta catenin
SpecificityThis is a highly specific antibody against Beta catenin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range650-700/781
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Beta catenin
Gene ID number1499
Swiss ProtP35222
Tested Applications IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APC, AXIN2, Acts as a negative regulator of centrosome cohesion, Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome, CTNNB1 is not ubiquitinated and accumulates in the nucleus, Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML, In the absence of Wnt, In the presence of Wnt ligand, Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization, Involved in the regulation of cell adhesion, forms a complex with AXIN1, leading to activate Wnt responsive genes, where it acts as a coactivator for transcription factors of the TCF/LEF family, Key downstream component of the canonical Wnt signaling pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Beta-catenin, CTNNB1, Catenin beta-1, MRD19, OK/SW-cl, PRO2286, armadillo, 35, CTNNB
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetBeta catenin
Short nameBeta catenin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameb catenin (Antibody to)
Alternative techniqueantibodies
Identity 2514
Gene CTNNB1
Long gene name catenin beta 1
Synonyms gene CTNNB
Synonyms gene name 88kDa catenin (cadherin-associated protein), beta 1, beta 1 , beta 1 (88kD) catenin (cadherin-associated protein), catenin (cadherin-associated protein)
Synonyms beta-catenin armadillo
Locus 3p22, 1
Discovery year 1993-07-13
GenBank acession X87838
Entrez gene record 1499
Pubmed identfication 7829088
RefSeq identity NM_001098210
Classification NineTeen complex Armadillo repeat containing
Havana BLAST/BLAT OTTHUMG00000131393
Locus Specific Databases LRG_1108

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