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Bub1 Antibody

Bub1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameBub1 Primary Polyclonal Antibody
Also known asBub1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBub1
SpecificityThis is a highly specific antibody against Bub1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range980-1030/1085
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bub1
Gene ID number699
Swiss ProtO43683
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1), BUB1B, CENPE and MAD2L1, Can phosphorylate BUB3, Can regulate chromosome segregation in a kinetochore-independent manner, Has a key role in the assembly of checkpoint proteins at the kinetochore, Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity, Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis, Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function, Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion, Required for the kinetochore localization of PLK1, The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20, This complex can also phosphorylate MAD1L1, being required for the subsequent localization of CENPF, Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BUB1, BUB1L, Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, BUB1A
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetBub1
Short nameBub1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namebudding uninhibited by benzimidazoles 1 homolog (yeast) (Antibody to)
Alternative techniqueantibodies
Identity 1150
Gene BUB1L
Long gene name BUB1 mitotic checkpoint serine/threonine kinase
Synonyms gene name budding uninhibited by benzimidazoles 1 (yeast homolog) budding uninhibited by benzimidazoles 1 homolog (yeast)
Synonyms hBUB1 BUB1A BUB1
Locus 2q13
Discovery year 1997-08-18
GenBank acession AF046078
Entrez gene record 699
RefSeq identity NM_004336
Havana BLAST/BLAT OTTHUMG00000153638

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