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CD117 Antibody

CD117 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCD117
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, FACS, WB
Recommended dilutionsFlow Cytometry: 1:10-1:50, Western blot: 1:1000
NotesTitration of the CD117 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis CD117 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P10721
PurityAntigen affinity
Description Altered forms of this receptor may be associated with some types of cancer, It is a receptor tyrosine kinase type III, Signalling through CD117 plays a role in cell survival, When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, [Wiki], also known as steel factor or c-kit ligand, and differentiation, proliferation, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell, which binds to stem cell factor (a substance that causes certain types of cells to grow), CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types
ImmunogenA portion of amino acids 680-711 from the human protein was used as the immunogen for this CD117 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CD117 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCD117
Short nameCD117 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCD117 (Antibody to)
Alternative techniqueantibodies
Identity 6342
Gene KIT
Long gene name KIT proto-oncogene receptor tyrosine kinase
Synonyms gene PBT
Synonyms gene name piebald trait v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Synonyms CD117 SCFR C-Kit
Locus 4q12
Discovery year 1986-01-01
GenBank acession S67773
Entrez gene record 3815
Pubmed identfication 9027509
RefSeq identity NM_000222
Classification CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000128713
Locus Specific Databases LRG_307

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