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CD163/M130 Antibody

CD163/M130 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCD163/M130 Primary Polyclonal Antibody
Also known asCD163/M130 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCD163/M130
SpecificityThis is a highly specific antibody against CD163/M130
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range800-850/1156
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD163/M130
Gene ID number9332
Swiss ProtQ86VB7
Tested Applications FCM, IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen After shedding, Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype, Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells, May play a role in the uptake and recycling of iron, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions, inositol triphosphate production and secretion of IL6 and CSF1, the soluble form (sCD163) may play an anti-inflammatory role, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme, Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CD163, Hemoglobin scavenger receptor, MM13, Scavenger receptor cysteine-rich type 1 protein M13, M13
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCD163/M130
Short nameCD163/M130 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCD163 molecule/M130 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target CD163 and IDBG-16292 and ENSG00000177575 and 9332, CD163 and IDBG-639861 and ENSBTAG00000019669 and 533844, Cd163 and IDBG-186721 and ENSMUSG00000008845 and 93671, Extracellular, M130 and MM130, protein binding, this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0016020 and membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component, this GO :0005044: scavenger receptor activity, this GO :0005044: scavenger receptor activity and also this GO :0005515: protein binding, this GO :0005515: protein binding, CD163 molecule
Identity 1631
Gene CD163
Long gene name CD163 molecule
Synonyms gene name CD163 antigen
Synonyms M130 MM130 SCARI1
Locus 12p13, 31
Discovery year 2000-01-18
GenBank acession Z22968
Entrez gene record 9332
Pubmed identfication 10403791 8370408
RefSeq identity NM_004244 NM_203416
Classification CD molecules Scavenger receptors
Havana BLAST/BLAT OTTHUMG00000168353

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