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Doppel/DPL Antibody

Doppel/DPL Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDoppel/DPL Primary Polyclonal Antibody
Also known asDoppel/DPL PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDoppel/DPL
SpecificityThis is a highly specific antibody against Doppel/DPL
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Doppel
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen BSE in cattle, Dpl does not appear to contribute to prion disease progression, Dpl is also thought to play a role in angiogenesis, Dpl is characterized by an alpha-helical conformation, Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice, Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, The PRND gene locus, and Cruetzfeldt-Jacob disease in humans, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor, and two N-linked oligosaccharides, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice, encodes for the doppel protein (Dpl), including scrapie in sheep, infectious or sporadic, intramolecular disulfide bonds, lethal neurodegenerative disorders involving alterations of the prion protein (PrP), located on human chromosome 20p, specifically maturation of the blood-brain barrier, which exhibits approximately 25% sequence homology with PrP, Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Dublet, MGC41841, PRND, PRND_HUMAN, PrPLP, Prion gene complex downstream, Prion like protein doppel, Prion protein 2, Prion protein 2 dublet, Prion-like protein doppel, DPL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDoppel/DPL
Short nameDoppel/DPL Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameDoppel/DPL (Antibody to)
Alternative techniqueantibodies
Identity 15748
Gene PRND
Long gene name prion like protein doppel
Synonyms gene name prion protein 2 (dublet)
Synonyms DPL dJ1068H6, 4 DOPPEL PrPLP
Synonyms name prion-like protein doppel downstream prion protein-like gene
Locus 20p13
Discovery year 2001-05-30
GenBank acession AF106918
Entrez gene record 23627
Pubmed identfication 10525406 10577243
RefSeq identity NM_012409
Havana BLAST/BLAT OTTHUMG00000031789

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