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FE65 Antibody

FE65 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFE65 Primary Polyclonal Antibody
Also known asFE65 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFE65
SpecificityThis is a highly specific antibody against FE65
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range225-265/710
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fe65 protein
Gene ID number322
Swiss ProtO00213
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain, Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s), Function in association with TSHZ3, Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis, Required for histone H4 acetylation at double-strand breaks (DSBs), SET and HDAC factors as a transcriptional repressor, probably explains its trancription activation activity, recruiting other pro-apoptosis factors such as MAPK8/JNK1, that inhibits the expression of CASP4, Transcription coregulator that can have both coactivator and corepressor functions
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names APBB1, Amyloid beta A4 precursor protein-binding family B member 1, FE65, MGC:9072, Protein Fe65, RIR
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFE65
Short nameFE65 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFE65 (Antibody to)
Alternative techniqueantibodies
Identity 581
Gene APBB1
Long gene name amyloid beta precursor protein binding family B member 1
Synonyms gene RIR
Synonyms gene name amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Synonyms Fe65
Locus 11p15, 4
Discovery year 1997-03-27
GenBank acession L77864
Entrez gene record 322
Pubmed identfication 8955346 8894693
RefSeq identity NM_001164
Havana BLAST/BLAT OTTHUMG00000165454

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